Summary
The growth of yeast cultures at supra-optimal temperatures up to 39°C and exposure in non-nutrient solution up to 52 °C has been examined for the induction of genetic change. Both sets of conditions lead to the induction of mutation to antibiotic resistance, mitotic gene conversion, crossing-over and mitotic chromosomal non-disjunction.
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Bridges, B A, Ashwood-Smith, M J, and Munson, R T. 1969. Susceptibility of mild thermal and of ionising radiation damage to the same recovery mechanisms in E coli. Biochem Biophys Res Comm, 35, 192–196.
Cox, B S, and Bevan, E A. 1962. Aneuploidy in yeast. New Phytol, 61, 342–355.
Davies, P J, Evans, W E, and Parry, J M. 1975. Mitotic recombination induced by chemical and physical agents in the yeast Saccharomyces cerevisiae. Mut Res, 29, 301–314.
Drake, J W. 1966. Spontaneous mutations accumulating in bacteriophase T4 in the complete absence of DNA replication. Proc Natl Acad Sci, USA, 55, 738–743.
Evans, W E. 1974. Studies upon the inactivation and repair of cellular damage induced by chemical and physical agents. Ph.D. thesis, University College of Swansea.
Evans, W E, and Parry, J M. 1972. The cross sensitivity to radiations, chemical mutagens and heat treatment of X-ray sensitive mutants of yeast. Molec gen Genet, 118, 261–271.
Fingham, J R S, and Day, P R. 1965. Fungal Genetics, 2nd ed. Blackwell Scientific Publications, Oxford.
Freese, E. 1963. Molecular mechanisms of mutation. In J. H. Taylor (ed.), Molecular Genetics, Part I, pp. 207–270. Johns Hopkins, Academic Press.
Gomez, R F, and Sinskey, A J. 1973. DNA strand breaks in treated Salmonella typhimurium LT-2 after exposure to nutritionally complex media. J Bacteriol, 115, 522–528.
Hunnable, E G, and Cox, B S. 1971. The genetic control of dark recombination in yeast. Mut Res, 13, 297–309.
James, A P, and Lee-Whiting, A. 1955. Radiation induced genetic segregation in vegetative cells of diploid yeast. Genetics, 40, 826–835.
Lindahl, T, and Nyberg, B. 1972. Rate of depurination of native DNA. Biochem, 11, 3611–3618.
Lindegren, D. 1972. The temperature influence on the spontaneous mutation rate. 1. Literature review. Heredity, 70, 165–168.
Parry, J M, and Cox, B S. 1965. Photoreactivation of UV induced reciprocal recombination, gene conversion and mutation to prototophy in Saccharomyces cerevisiae. J gen Microbiol, 40, 235–241.
Parry, J M. 1969. Comparison of the effects of ultraviolet light and ethylmethane sulphonate upon the frequency of mitotic recombinations in yeast. Molec Gen Genet, 106, 66–72.
Roman, H. 1958. Sur les recombinations nonréciproques chez Saccharomyces cerevisiae et sur les problèmes poses par les phénomènes. Ann Génét, 1, 11.
Schenberg-Frascino, A, and Moustagghi, E. 1972. Lethal and mutagenic effects of elevated temperatures in haploid yeast. I. Variation in sensitivity during the cell cycle. Molec Gen Genet, 115, 243–257.
Sherman, F. 1957. The heat in-activation and production of cytochrome deficiency in yeast. Exp Cell Res, 11, 659–660.
Woodcock, E, and Grigg, G W. 1972. Repair of thermally induced DNA breakage in E. coli Nature, New Biology, 237, 76–79.
Yorst, H T, Chaleff, R S, and Finerty, J P. 1967. Induction and mitotic recombination in Saccharomyces cerevisiae by ethyl methanesulphonate. Nature, 215, 660–661.
Zimmermann, F K, and Schwaier, R. 1967. Induction of mitotic gene-conversion with nitrous acid, l-methyl-3-nitro-l-nitrosoguanidine and other alkylating agents in Saccharomyces cerevisiae. Mol Gen Genet, 100, 63–76.
Zimmermann, F K. 1973. A yeast strain for visual screening of the reciprocal products of mitotic crossing-over. Mutation Res, 21, 83–91.
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Evans, W., Parry, J. The genetic effects of elevated temperature in the yeast, Saccharomyces cerevisiae. Heredity 35, 347–359 (1975). https://doi.org/10.1038/hdy.1975.105
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DOI: https://doi.org/10.1038/hdy.1975.105
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