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Current status and the future for the genetics of type I diabetes

Genes & Immunity volume 10, pages S128–S131 (2009)Cite this article

Abstract

The Type I Diabetes Genetics Consortium (T1DGC) is an international collaboration whose primary goal is to identify genes whose variants modify an individual's risk of type I diabetes (T1D). An integral part of the T1DGC's mission is the establishment of clinical and data resources that can be used by, and that are fully accessible to, the T1D research community (http://www.t1dgc.org). The T1DGC has organized the collection and analyses of study samples and conducted several major research projects focused on T1D gene discovery: a genome-wide linkage scan, an intensive evaluation of the human major histocompatibility complex, a detailed examination of published candidate genes, and a genome-wide association scan. These studies have provided important information to the scientific community regarding the function of specific genes or chromosomal regions on T1D risk. The results are continually being updated and displayed (http://www.t1dbase.org). The T1DGC welcomes all investigators interested in using these data for scientific endeavors on T1D. The T1DGC resources provide a framework for future research projects, including examination of structural variation, re-sequencing of candidate regions in a search for T1D-associated genes and causal variants, correlation of T1D risk genotypes with biomarkers obtained from T1DGC serum and plasma samples, and in-depth bioinformatics analyses.

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Acknowledgements

This research uses resources provided by the Type I Diabetes Genetics Consortium, a collaborative clinical study sponsored by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institute of Allergy and Infectious Diseases (NIAID), National Human Genome Research Institute (NHGRI), National Institute of Child Health and Human Development (NICHD), and Juvenile Diabetes Research Foundation International (JDRF) and supported by U01 DK062418. Further support was provided by a grant from the NIDDK (DK46635) to PC and a joint JDRF and Wellcome Trust grant to the Diabetes and Inflammation Laboratory at Cambridge that also received support from the National Institute for Health Research Cambridge Biomedical Research Centre.

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Authors and Affiliations

  1. Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USA

    S S Rich & P Concannon

  2. Department of Public Health Sciences, University of Virginia, Charlottesville, VA, USA

    S S Rich

  3. Division of Diabetes, Endocrinology, and Metabolic Diseases, The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health, Bethesda, MD, USA

    B Akolkar

  4. Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA, USA

    P Concannon

  5. Roche Molecular Systems, Pleasanton, CA, USA

    H Erlich

  6. Department of Biostatistics, School of Public Health, University of Alabama at Birmingham, Birmingham, AL, USA

    J E Hilner

  7. Inserm U730, Centre National de Génotypage, Evry, France

    C Julier

  8. Centre for Diabetes Research, The Western Australian Institute for Medical Research, and Centre for Medical Research, University of Western Australia, Perth, Australia

    G Morahan

  9. Hagendorn Research Institute and Steno Diabetes Center, Gentofte, Denmark

    J Nerup & F Pociot

  10. Juvenile Diabetes Research Foundation International, New York, NY, USA

    C Nierras

  11. Department of Medical Genetics, Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK

    J A Todd

Authors
  1. S S Rich
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  2. B Akolkar
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  3. P Concannon
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  4. H Erlich
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  5. J E Hilner
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  6. C Julier
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  7. G Morahan
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  8. J Nerup
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  9. C Nierras
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  10. F Pociot
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  11. J A Todd
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Correspondence to S S Rich.

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Rich, S., Akolkar, B., Concannon, P. et al. Current status and the future for the genetics of type I diabetes. Genes Immun 10 (Suppl 1), S128–S131 (2009). https://doi.org/10.1038/gene.2009.100

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