We wish to address our article ‘Retrobulbar optic neuritis after Hepatitis A vaccination in a HIV-infected patient’,1 in which we suggested a temporal association between Hepatitis A vaccination and optic neuritis. The patient’s subsequent progress is shown in Figure 1. As our patient sero-converted after the first dose, he did not receive further Hepatitis A or other vaccinations during the follow-up period.
He was diagnosed with multiple sclerosis (MS), 3 years after the occurrence of optic neuritis. We now feel that the initial two events are more likely coincidental than causative.
Since our earlier article, case reports continue to suggest an association between vaccination and optic neuritis.2, 3 Larger studies, however, are still unable to establish a definite link. Besides those mentioned previously, Liang et al4 recently reported the occurrence of three cases of optic neuritis in the post-marketing surveillance of 89.6 million doses of Influenza A (H1N1) vaccine in China, between September 2009 and March 2010, and concluded that there was no observable pattern of adverse events after the administration of influenza A (H1N1) vaccine. One caveat of this study is the passive reporting of adverse events making underreporting likely. Despite this, the incidence of optic neuritis (post-vaccination) is 0.003 cases per 100 000 doses, much lower than the rate of 0.89 per 100 000 for optic neuritis in Singaporean Chinese.5
On longer follow-up of this patient, it appears that the two events are more likely coincidental. We feel that patients who develop post-vaccination optic neuritis should be followed up as they may develop demyelinating syndromes years later.
References
Huang EH, Lim SA, Lim PL, Leo YS . Retrobulbar optic neuritis after Hepatitis A vaccination in a HIV-infected patient. Eye 2009; 23 (12): 2267–2271.
Sutton I, Lahoria R, Tan I, Clouston P, Barnett M . CNS demyelination and quadrivalent HPV vaccination. Mult Scler 2009; 15 (1): 116–119.
Jo DH, Kim SJ, Chae JH, Yu YS . The clinical characteristics of optic neuritis in Korean children. Korean J Ophthalmol 2011; 25 (2): 116–120.
Liang XF, Li L, Liu DW, Li KL, Wu WD, Zhu BP et al. Safety of influenza A (H1N1) vaccine in postmarketing surveillance in China. N Engl J Med 2011; 364 (7): 638–647; Erratum in: N Engl J Med 2011; 364(15): 1481.
Lim SA, Wong WL, Fu E, Goh KY, Seah A, Tan C et al. The incidence of neuro-ophthalmic diseases in Singapore: a prospective study in public hospitals. Ophthalmic Epidemiol 2009; 16 (2): 65–73.
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Sudarshan, S., Huang, E., Lim, P. et al. A case of post-vaccination optic neuritis: coincidence or causative?. Eye 26, 1498 (2012). https://doi.org/10.1038/eye.2012.146
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DOI: https://doi.org/10.1038/eye.2012.146