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Taurolidine locks significantly reduce the incidence of catheter-related blood stream infections in high-risk patients on home parenteral nutrition

European Journal of Clinical Nutrition volume 69, pages 282–284 (2015)Cite this article

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Abstract

Emerging evidence suggests taurolidine reduces the risk of repeated episodes of catheter related blood stream infections (CRBSI) in a subgroup of patients receiving home parenteral nutrition (HPN). We defined 3 indications where taurolidine could be considered and retrospectively analysed data from patients who were treated over a 10 year period to examine the validity of these criteria. Twenty-two patients were identified from a total HPN population of 81, representing 33.2 years of experience. The overall CRBSI rate pre- and post-taurolidine usage was reduced from 5.71 to 0.99 infections per 1000 patient parenteral nutrition days (P-value <0.0001), with reductions identified in each smaller subgroup, confirming previous reports of a significant reduction in infections when taurolidine is used as secondary prophylaxis and providing initial data suggesting the benefit of its use as primary prophylaxis.

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Authors and Affiliations

  1. Southampton NIHR Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, University of Southampton, Southampton, UK

    J Saunders, M Naghibi, C Parsons, T Smith & M Stroud

  2. Department of Nutrition and Dietetics, University Hospital Southampton, Southampton, UK

    Z Leach

  3. Department of Surgery, University Hospital Southampton, Southampton, UK

    A King

Authors
  1. J Saunders
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  2. M Naghibi
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  3. Z Leach
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  4. C Parsons
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  5. A King
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  6. T Smith
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  7. M Stroud
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Correspondence to M Stroud.

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The authors declare no conflict of interest.

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Contributors: JS conceived the study, carried out the study, data analysis and drafted the manuscript. MN carried out the study, data analysis and helped draft the manuscript. MN carried out the study, data analysis and helped draft the manuscript. ZL carried out data collection and helped draft the manuscript. CP carried out data analysis and performed statistical analysis. AK conceived the study, participated in its design and coordination and helped write the manuscript. TS conceived the study, participated in its design and coordination and helped write the manuscript. MS conceived the study, participated in its design and coordination and helped write the manuscript (guarantor of article). All authors approved the final version of the article including the authorship list.

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Saunders, J., Naghibi, M., Leach, Z. et al. Taurolidine locks significantly reduce the incidence of catheter-related blood stream infections in high-risk patients on home parenteral nutrition. Eur J Clin Nutr 69, 282–284 (2015). https://doi.org/10.1038/ejcn.2014.32

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  • DOI: https://doi.org/10.1038/ejcn.2014.32

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