Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Original Article
  • Published:

Epidemiology

Correlation of serum adiponectin and adiponectin gene polymorphism with metabolic syndrome in Chinese adolescents

European Journal of Clinical Nutrition volume 69, pages 62–67 (2015)Cite this article

Subjects

Abstract

Background/objectives:

To investigate the association of adiponectin and its gene polymorphisms with metabolic syndrome (MetS) and cardiovascular disease (CVD) risk factors in Chinese adolescents.

Subjects/methods:

This cross-sectional study enrolled 919 healthy middle school students (aged 11–16 years; 46.7% females). All participants underwent anthropometric and biochemical examinations, and MetS was diagnosed using 2007 International Diabetes Federation criteria. The presence of adiponectin and its genotypes of single nucleotide polymorphisms (SNPs) rs266729 (−11377C/G), rs2241766 (+45T/G) and rs1501299 (+276G/T) was detected.

Results:

(1) Serum adiponectin levels were negatively correlated with numerous CVD risk factors (all P<0.05), and following adjustments for confounding factors, a lower adiponectin level was an independent risk factor for MetS (odds ratio=5.59; 95% confidence interval: 1.90, 16.41). Central obesity and low levels of high-density lipoprotein cholesterol were positively associated with MetS and reduced serum adiponectin levels. (2) The genotype and frequencies of SNP-11377 and SNP+276 in a MetS group and non-MetS group were not significantly different. Subjects with genotype SNP+45 GG were at higher risk for MetS compared with subjects with genotypes SNP+45 TT (P=0.033) or TT+TG (P=0.021). Subjects with genotype SNP+276 TT or TT+TG had higher levels of serum adiponectin compared with subjects with SNP+276 GG (P=0.012 and 0.014, respectively).

Conclusions:

Adiponectin may be used as a predictive biomarker of MetS, and shows a significant association with CVD risk factors in Chinese adolescents. Adiponectin gene polymorphisms are associated with serum adiponectin concentrations and the presence of MetS.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1
Figure 2

Similar content being viewed by others

References

  1. Li FY, Cheng KK, Lam KS, Vanhoutte PM, Xu A . Cross-talk between adipose tissue and vasculature: role of adiponectin. Acta Physiol (Oxf) 2011; 203: 167–180.

    Article  CAS  Google Scholar 

  2. Yu D, Yu Z, Sun Q, Sun L, Li H, Song J et al. Effects of body fat on the associations of high-molecular-weight adiponectin, leptin and soluble leptin receptor with metabolic syndrome in Chinese. PLoS One 2011; 6: e16818.

    Article  CAS  Google Scholar 

  3. Siitonen N, Pulkkinen L, Lindström J, Kolehmainen M, Eriksson JG, Venojärvi M et al. Association of ADIPOQ gene variants with body weight, type 2 diabetes and serum adiponectin concentrations: the Finnish Diabetes Prevention Study. BMC Med Genet 2011; 12: 5.

    Article  CAS  Google Scholar 

  4. Gong M, Long J, Liu Q, Deng HC . Association of the ADIPOQ rs17360539 and rs266729 polymorphisms with type 2 diabetes: a meta-analysis. Mol Cell Endocrinol 2010; 325: 78–83.

    Article  CAS  Google Scholar 

  5. Chang YC, Jiang JY, Jiang YD, Chiang FT, Hwang JJ, Lien WP et al. Interaction of ADIPOQ genetic polymorphism with blood pressure and plasma cholesterol level on the risk of coronary artery disease. Circ J 2009; 73: 1934–1938.

    Article  Google Scholar 

  6. Wang Y, Zhang D, Liu Y, Yang Y, Zhao T, Xu J et al. Association study of the single nucleotide polymorphisms in adiponectin-associated genes with type 2 diabetes in Han Chinese. J Genet Genomics 2009; 36: 417–423.

    Article  CAS  Google Scholar 

  7. Liu F, He Z, Deng S, Zhang H, Li N, Xu J . Association of adiponectin gene polymorphisms with the risk of ischemic stroke in a Chinese Han population. Mol Biol Rep 2011; 38: 1983–1988.

    Article  CAS  Google Scholar 

  8. Ong KL, Li M, Tso AW, Xu A, Cherny SS, Sham PC et al. Association of genetic variants in the adiponectin gene with adiponectin level and hypertension in Hong Kong Chinese. Eur J Endocrinol 2010; 163: 251–257.

    Article  CAS  Google Scholar 

  9. Friedewald WT, Levy RI, Fredrickson DS . Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 1972; 18: 499–502.

    CAS  Google Scholar 

  10. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC . Homeostasis model assessment: insulin resistance and b cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985; 28: 412–419.

    Article  CAS  Google Scholar 

  11. Zimmet P, Alberti G, Kaufman F, Tajima N, Silink M, Arslanian S et al. The metabolic syndrome in children and adolescents. Lancet 2007; 369: 2059–2061.

    Article  Google Scholar 

  12. Xi B, Mi J, Wang L, Duan JL, Zhao D, Zhang MM et al. Family aggregation of primary hypertension among children and adolescents in Belling. Chin J Epidemiol 2008; 29: 849–854.

    Google Scholar 

  13. Boyraz M, Cekmez F, Karaoğlu A, Cinaz P, Durak M, Bideci A . Relationship of adipokines (adiponectin, resistin and RBP4) with metabolic syndromecomponents in pubertal obese children. Biomark Med 2013; 7: 423–428.

    Article  CAS  Google Scholar 

  14. Klünder-Klünder M, Flores-Huerta S, García-Macedo R, Peralta-Romero J, Cruz M . Adiponectin in eutrophic and obese children as a biomarker to predict metabolic syndrome and each of its components. BMC Public Health 2013; 13: 88.

    Article  Google Scholar 

  15. Papoutsakis C, Yannakoulia M, Ntalla I, Dedoussis GV . Metabolic syndrome in a Mediterranean pediatric cohort: prevalence using International Diabetes Federation-derived criteria and associations with adiponectin and leptin. Metabolism 2012; 61: 140–145.

    Article  CAS  Google Scholar 

  16. Riestra P, García-Anguita A, Lasunción MA, Cano B, de Oya M, Garcés C . Relationship of adiponectin with metabolic syndrome components in pubertal children. Atherosclerosis 2011; 216: 467–470.

    Article  CAS  Google Scholar 

  17. Morrison JA, Glueck CJ, Daniels S, Wang P, Stroop D . Paradoxically high adiponectin in obese 16-year-old girls protects against appearance of the metabolic syndrome and its components seven years later. J Pediatr 2011; 158: 208–214.

    Article  CAS  Google Scholar 

  18. González M, del Mar Bibiloni M, Pons A, Llompart I, Tur JA . Inflammatory markers and metabolic syndrome among adolescents. Eur J Clin Nutr 2012; 66: 1141–1145.

    Article  Google Scholar 

  19. Abiko A, Makita S, Naganuma Y, Nagai M, Nakamura M . Association between metabolic syndrome and carotid atherosclerosis: relevance of combined criteria including the serum adiponectin level for the general population. Intern Med 2011; 50: 381–387.

    Article  CAS  Google Scholar 

  20. Petrone A, Zavarella S, Caiazzo A, Leto G, Spoletini M, Potenziani S et al. The promoter region of the adiponectin gene is a determinant in modulating insulin sensitivity in childhood obesity. Obesity (Silver Spring) 2006; 14: 1498–1504.

    Article  CAS  Google Scholar 

  21. Bouatia-Naji N, Meyre D, Lobbens S, Séron K, Fumeron F, Balkau B et al. ACDC/adiponectin polymorphisms are associated with severe childhood and adult obesity. Diabetes 2006; 55: 545–550.

    Article  CAS  Google Scholar 

  22. Li Y, Li X, Shi L, Yang M, Yang Y, Tao W et al. Association of adiponectin SNP+45 and SNP+276 with type 2 diabetes in Han Chinese populations: a meta-analysis of 26 case-control studies. PLoS One 2011; 6: e19686.

    Article  CAS  Google Scholar 

  23. Ntalla I, Dedoussis G, Yannakoulia M, Smart MC, Louizou E, Sakka SD et al. ADIPOQ gene polymorphism rs1501299 interacts with fibre intake to affect adiponectin concentration in children: the GENe-Diet Attica Investigation on childhood obesity. Eur J Nutr 2009; 48: 493–497.

    Article  CAS  Google Scholar 

  24. Ebinuma H, Miyazaki O, Yago H, Hara K, Yamauchi T, Kadowaki T . A novel ELISA system for selective measurement of human adiponectin multimers by using proteases. Clin Chim Acta 2006; 372: 47–53.

    Article  CAS  Google Scholar 

  25. Luo N, Chung BH, Wang X, Klein RL, Tang CK, Garvey WT et al. Enhanced adiponectin actions by overexpression of adiponectin receptor 1 in macrophages. Atherosclerosis 2013; 228: 124–135.

    Article  CAS  Google Scholar 

Download references

Acknowledgements

This work was completed with funding from the scientific and technological planning project of Liaoning Province (grant numbers 2008225009-21).

Author information

Authors and Affiliations

  1. Department of Endocrinology, Shengjing Hospital of China Medical University, Shenyang, PR China

    P Li, L Li, C Liu, F Yang & Y Qiu

  2. Liaoyang Diabetes Hospital, Liaoyang, PR China

    R Jiang

  3. The Liaoning Provincial Key Laboratory of Endocrine Diseases, Shenyang, PR China

    L Li

Authors
  1. P Li
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. R Jiang
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. L Li
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. C Liu
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. F Yang
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Y Qiu
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to L Li.

Ethics declarations

Competing interests

The authors declare no conflict of interest.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Li, P., Jiang, R., Li, L. et al. Correlation of serum adiponectin and adiponectin gene polymorphism with metabolic syndrome in Chinese adolescents. Eur J Clin Nutr 69, 62–67 (2015). https://doi.org/10.1038/ejcn.2014.152

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/ejcn.2014.152

This article is cited by

Search

Advanced search

Quick links