Abstract
Background/Objectives:
Carotenoids are potentially malabsorbed in patients with chronic pancreatitis (CP). The aims of this study were: (1) to determine the prevalence of low levels of each of the major carotenoids in subjects with CP; (2) to compare carotenoids in CP subjects with or without vascular disease and (3) to test the effect of an increase in dietary lycopene intake in patients with low plasma lycopene concentration.
Subjects/Methods:
Simultaneous determination of carotenoids was done in 80 patients with CP and 20 healthy subjects, using high-performance liquid chromatography. Of the CP patients who had low lycopene concentration, 22 (<120 μg/l) had to consume daily 40 g tomato paste (approximately 24 mg lycopene).
Results:
Of these patients, 84.7% had at least one carotenoid deficiency and 27.5% had more than four carotenoid deficiencies. Low plasma concentrations in β-carotene and lycopene were correlated, in CP group, with a low body mass index (BMI), a low low-density lipoprotein (LDL) cholesterol concentration, alcohol consumption and current smoking status, whereas low plasma concentration in β-cryptoxanthine was correlated with a low BMI, a low LDL cholesterol concentration and alcohol consumption. Lycopene concentration was decreased in patients with vascular disease (171±197 vs 99±72 μg/l; P=0.02). After an intervention period of 8±2 months, lycopene concentration increased from 67.5±30 to 121.8±102 μg/l (P=0.025).
Conclusion:
Carotenoid concentrations are dramatically decreased in CP, especially lycopene in CP patients with vascular disease. Despite malabsorption, it is possible to increase lycopene plasma concentration by increasing heated tomato consumption.
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References
Ahmed S, Leo MA, Lieber CS (1994). Interactions between alcohol and beta-carotene in patients with alcoholic liver disease. Am J Clin Nutr 60, 430–436.
Albanes D, Virtamo J, Taylor PR, Rautalahti M, Pietinen P, Heinonen OP (1997). Effects of supplemental beta-carotene cigarette smoking and alcohol consumption on serum carotenoids in the Alpha-Tocopherol Beta-Carotene Cancer Prevention Study. Am J Clin Nutr 66, 366–372.
Bendich A, Olson JA (1989). Biological actions of carotenoids. FASEB J 3, 1927–1932.
Brady WE, Mares-Perlman JA, Bowen P, Stacewicz-Sapuntzakis M (1996). Human serum carotenoid concentrations are related to physiologic and lifestyle factors. J Nutr 126, 129–137.
Brown ED, Micozzi MS, Craft NE, Bieri JG, Beecher G, Edwards BK et al. (1989). Plasma carotenoids in normal men after a single ingestion of vegetables or purified beta-carotene. Am J Clin Nutr 49, 1258–1265.
Burney PG, Comstock GW, Morris JS (1989). Serologic precursors of cancer serum micronutrients and the subsequent risk of pancreatic cancer. Am J Clin Nutr 49, 895–900.
Clevidence BA, Bieri JG (1993). Association of carotenoids with human plasma lipoproteins. Methods Enzymol 214, 33–46.
Comstock GW, Helzlsouer KJ, Bush TL (1991). Prediagnostic serum levels of carotenoids and vitamin E as related to subsequent cancer in Washington County Maryland. Am J Clin Nutr 53, 260S–264S.
De Backer G, Ambrosioni E, Borch-Johnsen K, Brotons C, Cifkova R, Dallongeville J et al. (2004). European guidelines on cardiovascular disease prevention in clinical practice. Third Joint Task Force Of European and other societies on cardiovascular disease prevention in clinical practice. Arch Mal Coeur Vaiss 97, 1019–1030.
Dujsikova H, Dite P, Tomandl J, Sevcikova A, Precechtelova M (2008). Occurrence of metabolic osteopathy in patients with chronic pancreatitis. Pancreatology 29, 583–586.
Dutta SK, Bustin MP, Russell RM, Costa BS (1982). Deficiency of fat-soluble vitamins in treated patients with pancreatic insufficiency. Ann Intern Med 97, 549–552.
Farwell WR, Michael Gaziano J, Norkus EP, Sesso HD (2008). The relationship between total plasma carotenoids and risk factors for chronic disease among middle-aged and older men. Br J Nutr 100, 883–889.
Forman MR, Beecher GR, Lanza E, Reichman ME, Graubard BI, Campbell WS et al. (1995). Effect of alcohol consumption on plasma carotenoid concentrations in premenopausal women: a controlled dietary study. Am J Clin Nutr 62, 131–135.
Franz MJ, Boucher JL, Green-Pastors J, Powers MA (2008). Evidence-based nutrition practice guidelines for diabetes and scope and standards of practice. J Am Diet Assoc 108, S52–S58.
Granado F, Olmedilla B, Blanco I (2003). Nutritional and clinical relevance of lutein in human health. Br J Nutr 90, 487–502.
Gärtner C, Stahl W, Sies H (1997). Lycopene is more bioavailable from tomato paste than from fresh tomatoes. Am J Clin Nutr 66, 116–122.
Haaber AB, Rosenfalck AM, Hansen B, Hilsted J, Larsen S (2000). Bone mineral metabolism bone mineral density and body composition in patients with chronic pancreatitis and pancreatic exocrine insufficiency. Int J Pancreatol 27, 21–27.
Handelman GJ, Packer L, Cross CE (1996). Destruction of tocopherols carotenoids and retinol in human plasma by cigarette smoke. Am J Clin Nutr 63, 55965.
Ito Y, Sasaki S, Suzuki S, Aoki K (1991). Relationship between serum xanthophyll levels and the consumption of cigarettes, alcohol or foods in healthy inhabitants of Japan. Int J Epidemiol 20, 615–620.
Micozzi MS, Brown ED, Edwards BK, Bieri JG, Taylor PR, Khachik F et al. (1992). Plasma carotenoid response to chronic intake of selected foods and beta-carotene supplements in men. Am J Clin Nutr 55, 1120–1125.
Pamuk ER, Byers T, Coates RJ, Vann JW, Sowell AL, Gunter EW et al. (1994). Effect of smoking on serum nutrient concentrations in African-American women. Am J Clin Nutr 59, 891–895.
Princen HM, Poppel G, Vogelezang C, Buytenhek R, Kok FJ (1992). Supplementation with vitamin E but not beta-carotene in vivo protects low density lipoproteins from lipid peroxidation in vitro. Arterioscler Thromb 12, 554–562.
Puel J, Valensi P, Vanzetto G, Lassmann-Vague V, Monin JL, Moulin P et al. (2004). Identification of myocardial ischemia in the diabetic patient. Joint ALFEDIAM and SFC recommendations. Diabetes Metab 30, 3S3–3S18.
Quilliot D, Dousset B, Guerci B, Dubois F, Drouin P, Ziegler O (2001). Evidence that diabetes mellitus favors impaired metabolism of zinc, copper, and selenium in chronic pancreatitis. Pancreas 22, 299–306.
Quilliot D, Walters E, Bonte JP, Fruchart JC, Duriez P, Ziegler O (2005). Diabetes mellitus worsens antioxidant status in patients with chronic pancreatitis. Am J Clin Nutr 81, 1117–1125.
Rao LG, Mackinnon ES, Josse RG, Murray TM, Strauss A, Rao AV (2007). Lycopene consumption decreases oxidative stress and bone resorption markers in postmenopausal women. Osteoporos Int 18, 109–115.
Russell R (2006). The multifunctional carotenoids: insights into their behaviour. J Nutr 136, 1690S–2692S.
Schoenberg MH, Birk D, Beger HG (1995). Oxidative stress in acute and chronic pancreatitis. Am J Clin Nutr 62, 1306S–1314S.
Stahl W, Sies H (1992). Uptake of lycopene and its geometrical isomers is greater from heat-processed than from unprocessed tomato juice in humans. J Nutr 122, 2161–2166.
Steinberg D, Witztum JL (1990). Lipoproteins and atherogenesis. Current concepts. JAMA 264, 30–47.
Sweiry JH, Mann GE (1996). Role of oxidative stress in the pathogenesis of acute pancreatitis. Scand J Gastroenterol (Suppl) 219, 10–15.
Tanabe N, Toyoshima H, Hayashi S, Miyanishi K, Funazaki T, Obata A et al. (1992). Effects of smoking and drinking habits and vitamin A intake on serum concentrations of beta-carotene and retinol. Nippon Eiseigaku Zasshi 47, 679–687.
Van Antwerpen VL, Theron AJ, Richard GA, Van Der Merwe CA, Van der Walt R, Anderson R (1995). Relationship between the plasma levels of beta-carotene and lung functions in cigarette smokers. Int J Vitam Nutr Res 65, 231–235.
Van de Kamer JH, Bockel H, Weijers HA (1949). Rapid method for the determination of fat in feces. J Biol Chem 177, 347–355.
Vogel S, Contois JH, Tucker KL, Wilson PW, Schaefer EJ, Lammi-Keefe CJ (1997). Plasma retinol and plasma and lipoprotein tocopherol and carotenoid concentrations in healthy elderly participants of the Framingham Heart Study. Am J Clin Nutr 66, 950–958.
Voutilainen S, Nurmi T, Mursu J, Rissanen TH (2006). Carotenoids and cardiovascular health. Am J Clin Nutr 83, 1265–1271.
Vuoristo M, Vänen H, Miettinen TA (1992). Cholesterol malabsorption in pancreatic insufficiency: effects of enzyme substitution. Gastroenterology 102, 647–655.
Woutersen RA, Appel MJ, Van Garderen-Hoetmer A (1999). Modulation of pancreatic carcinogenesis by antioxidants. Food Chem Toxicol 37, 981–984.
Yadav S, Day JP, Mohan V, Snehalatha C, Braganza JM (1991). Selenium and diabetes in the tropics. Pancreas 6, 528–533.
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Contributors: DQ had responsibility for the conception and organization of the study, analysis of the results, subject recruitment and writing. AF had responsibility for analysis of the results and writing the manuscript. FD had responsibility for laboratory analysis and analysis of the results. OZ had responsibility for clinical department management, the conceptual basis of the study and analysis of the results.
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Quilliot, D., Forbes, A., Dubois, F. et al. Carotenoid deficiency in chronic pancreatitis: the effect of an increase in tomato consumption. Eur J Clin Nutr 65, 262–268 (2011). https://doi.org/10.1038/ejcn.2010.232
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DOI: https://doi.org/10.1038/ejcn.2010.232
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