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Young brain fluid improves memory in old mice

A protein in cerebrospinal fluid helps boost cells that maintain brain function.
  1. Jude Coleman
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Scientists have been trying to unravel the mysteries of why memory diminishes with age for decades. Now they have discovered a possible remedy — cerebrospinal fluid from younger brains1.

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doi: https://doi.org/10.1038/d41586-022-01282-1

Updates & Corrections

  • Update 12 May 2022: This story has been updated to include details of Tony Wyss-Coray and Tal Iram's patent application.

  • Correction 13 May 2022: A previous version of this story misstated the results of the trial in mice.

References

  1. Iram, T. et al. Nature 605, 509–515 (2022).

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  2. Villeda, S. et al. Nature Med. 20, 659–663 (2014).

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  3. Castellano, J. et al. Nature 544, 488–492 (2017).

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  4. Zawadzki, M. & Lehtinen, M. K. Nature https://doi.org/10.1038/d41586-022-00860-7 (2022).

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