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The open-access Protein Data Bank (PDB) serves as the single global repository for 3D structural data of proteins, DNA, RNA and their complexes with small molecules. Westbrook and Burley quantitatively assess the impact of the PDB on the discovery and development of 210 new molecular entities (NMEs) approved by the FDA between 2010 and 2016. Analysis of the PDB revealed 5,914 unique structures covering 88% of the NMEs and 86% of their known protein targets. More than half of the 5,914 structures had been deposited in the PDB well before the NME was approved by the FDA. Approximately 10% of worldwide research on the known molecular targets of the 210 NMEs was influenced by structural data from the PDB.
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Nature Reviews Drug Discovery18, 98 (2019)
doi: https://doi.org/10.1038/d41573-019-00010-1
References
Westbrook, J. D. & Burley, S. K. How structural biologists and the Protein Data Bank contributed to recent FDA new drug approvals. Structure https://doi.org/10.1016/j.str.2018.11.007 (2019)
