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References
Chang JT, Wherry EJ, Goldrath AW. Molecular regulation of effector and memory T cell differentiation. Nat Immunol 2014; 15: 1104–1115.
Wherry EJ, Kurachi M. Molecular and cellular insights into T cell exhaustion. Nat Rev Immunol 2015; 15: 486–499.
Ji Y, Hocker JD, Gattinoni L. Enhancing adoptive T cell immunotherapy with microRNA therapeutics. Semin Immunol 2016; 28: 45–53.
Steiner DF, Thomas MF, Hu JK, Yang Z, Babiarz JE, Allen CD et al. MicroRNA-29 regulates T-box transcription factors and interferon-gamma production in helper T cells. Immunity 2011; 35: 169–181.
Moffett HF, Cartwright ANR, Kim HJ, Godec J, Pyrdol J, Aijo T et al. The microRNA miR-31 inhibits CD8+ T cell function in chronic viral infection. Nat Immunol 2017; 18: 791–799.
Snell LM, McGaha TL, Brooks DG, Type I. Interferon in chronic virus infection and cancer. Trends Immunol 2017; 38: 542–557.
Acknowledgements
We thank Sumin Hwang for the editorial assistance. This work was supported by CNU Research Grant (2016-1531-01), a grant for Institute of Drug Research and Development in College of Pharmacy (CNU) (Natonal Research Foundation of Korea).
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Li, L., Hwang, I. Crucial role of miR-31 in induction of CD8+ T-cell exhaustion and reinforcement of type 1 interferon signaling. Cell Mol Immunol 15, 651–653 (2018). https://doi.org/10.1038/cmi.2017.96
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DOI: https://doi.org/10.1038/cmi.2017.96