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The GSTP1 gene variant rs1695 is not associated with an increased risk of multiple sclerosis

Cellular & Molecular Immunology volume 12, pages 777–779 (2015)Cite this article

We analyzed the allelic and genotypic frequencies of the glutathione-S-transferase P1 (GSTP1) rs1695 single nucleotide polymorphism (SNP) in 290 patients with multiple sclerosis (MS) and in 310 healthy controls. We found no significant association between the rs1695 variant and MS. Among MS patients, there was no relationship between the rs1695 variant and either gender, clinical type of MS or the age of onset of MS. These results suggest that the GSTP1 rs1695 polymorphism is not a risk factor for MS.

Genome-wide association studies in samples from MS patients have identified more than 100 loci with genome-wide significance, but most of these loci had a modest odds ratio (OR) in the range of 1.1–1.3; only HLA (especially the HLA-DRB1*15:01 haplotype) had a strong association with MS risk.1 A possible role for oxidative stress and lipid peroxidation in the pathogenesis of MS has been suggested by the presence of oxidative stress markers in the spinal cord, brain, and cerebrospinal fluid of MS patients and in experimental autoimmune encephalomyelitis (reviewed in Ref. 1).

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Acknowledgements

This work was supported in part by Grants PI12/00241, PI12/00324 and RETICS RD12/0013/0002 from Fondo de Investigación Sanitaria, Instituto de Salud Carlos III, Spain and GR10068 from Junta de Extremadura, Spain. Financed in part with FEDER funds from the European Union.

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Authors and Affiliations

  1. Department of Pharmacology, University of Extremadura, Cáceres, Spain

    José AG Agúndez & Carmen Martínez

  2. Department of Biochemistry and Molecular Biology, University of Extremadura, Cáceres, Spain

    Elena García-Martín

  3. CIBERNED, Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Instituto de Salud Carlos III, Spain

    Julián Benito-León

  4. Service of Neurology, Hospital Universitario Doce de Octubre, Madrid, Spain

    Julián Benito-León, María Díaz-Sánchez & Patricia Calleja

  5. Department of Medicine, University Complutense, Madrid, Spain

    Julián Benito-León, María Díaz-Sánchez & Patricia Calleja

  6. Section of Neurology, Hospital La Mancha-Centro, Alcázar de San Juan (Ciudad Real), Spain

    Jorge Millán-Pascual, Laura Turpín-Fenoll & Hortensia Alonso-Navarro

  7. Centro de Biología Molecular Severo Ochoa (CSIC-UAM), Facultad de Ciencias, Universidad Autónoma, Cantoblanco, Madrid, 28049, Spain

    Diana Pisa

  8. Department of Medicine-Neurology, Hospital ‘Príncipe de Asturias’, Universidad de Alcalá, Alcalá de Henares (Madrid), Spain

    Hortensia Alonso-Navarro, Lucía Ayuso-Peralta, Dolores Torrecillas, Esteban García-Albea & Félix Javier Jiménez-Jiménez

  9. Section of Neurology, Hospital Universitario del Sureste, Arganda del Rey (Madrid), Spain

    Hortensia Alonso-Navarro, José Francisco Plaza-Nieto & Félix Javier Jiménez-Jiménez

Authors
  1. José AG Agúndez
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  2. Elena García-Martín
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  4. Julián Benito-León
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  5. Jorge Millán-Pascual
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  6. María Díaz-Sánchez
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  7. Patricia Calleja
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  8. Diana Pisa
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  9. Laura Turpín-Fenoll
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  10. Hortensia Alonso-Navarro
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  11. Lucía Ayuso-Peralta
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  12. Dolores Torrecillas
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  13. Esteban García-Albea
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  14. José Francisco Plaza-Nieto
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  15. Félix Javier Jiménez-Jiménez
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Corresponding author

Correspondence to Félix Javier Jiménez-Jiménez.

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Agúndez, J., García-Martín, E., Martínez, C. et al. The GSTP1 gene variant rs1695 is not associated with an increased risk of multiple sclerosis. Cell Mol Immunol 12, 777–779 (2015). https://doi.org/10.1038/cmi.2014.121

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