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References
Pierson W, Cauwe B, Policheni A, Schlenner SM, Franckaert D, Berges J et al. Antiapoptotic Mcl-1 is critical for the survival and niche-filling capacity of Foxp3+ regulatory T cells. Nat Immunol 2013; 14: 959–965.
Fontenot JD, Gavin MA, Rudensky AY . Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Nat Immunol 2003; 4: 330–336.
Hori S, Nomura T, Sakaguchi S . Control of regulatory T cell development by the transcription factor Foxp3. Science 2003; 299: 1057–1061.
Nishikawa H, Sakaguchi S . Regulatory T cells in tumor immunity. Int J Cancer 2010; 127: 759–767.
Viglietta V, Baecher-Allan C, Weiner HL, Hafler DA . Loss of functional suppression by CD4+CD25+ regulatory T cells in patients with multiple sclerosis. J Exp Med 2004; 199: 971–979.
Wan S, Xia C, Morel L . IL-6 produced by dendritic cells from lupus-prone mice inhibits CD4+CD25+ T cell regulatory functions. J Immunol 2007; 178: 271–279.
Zhou X, Bailey-Bucktrout SL, Jeker LT, Penaranda C, Martinez-Llordella M, Ashby M et al. Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo. Nat Immunol 2009; 10: 1000–1007.
Takahashi T, Kuniyasu Y, Toda M, Sakaguchi N, Itoh M, Iwata M et al. Immunologic self-tolerance maintained by CD25+CD4+ naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state. Int Immunol 1998; 10: 1969–1980.
Annacker O, Pimenta-Araujo R, Burlen-Defranoux O, Barbosa TC, Cumano A, Bandeira A . CD25+CD4+ T cells regulate the expansion of peripheral CD4 T cells through the production of IL-10. J Immunol 2001; 166: 3008–3018.
Shi Y, Radvanyi LG, Sharma A, Shaw P, Green DR, Miller RG et al. CD28-mediated signaling in vivo prevents activation-induced apoptosis in the thymus and alters peripheral lymphocyte homeostasis. J Immunol 1995; 155: 1829–1837.
Swat W, Ignatowicz L, von Boehmer H, Kisielow P . Clonal deletion of immature CD4+8+ thymocytes in suspension culture by extrathymic antigen-presenting cells. Nature 1991; 351: 150–153.
Kurokawa M, Kornbluth S . Caspases and kinases in a death grip. Cell 2009; 138: 838–854.
Huang DC, Strasser A . BH3-only proteins-essential initiators of apoptotic cell death. Cell 2000; 103: 839–842.
Bouillet P, O'Reilly LA . CD95, BIM and T cell homeostasis. Nat Rev Immunol 2009; 9: 514–519.
Hernandez JB, Newton RH, Walsh CM . Life and death in the thymus—cell death signaling during T cell development. Curr Opin Cell Biol 2010; 22: 865–871.
Hildeman D, Jorgensen T, Kappler J, Marrack P . Apoptosis and the homeostatic control of immune responses. Curr Opin Immunol 2007; 19: 516–521.
Marsden VS, Strasser A . Control of apoptosis in the immune system: Bcl-2, BH3-only proteins and more. Annu Rev Immunol 2003; 21: 71–105.
Jamshidian A, Shaygannejad V, Pourazar A, Zarkesh-Esfahani SH, Gharagozloo M . Biased Treg/Th17 balance away from regulatory toward inflammatory phenotype in relapsed multiple sclerosis and its correlation with severity of symptoms. J Neuroimmunol 2013; 262: 106–112.
Chen W, Jin W, Hardegen N, Lei KJ, Li L, Marinos N et al. Conversion of peripheral CD4+CD25− naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3. J Exp Med 2003; 198: 1875–1886.
Collison LW, Chaturvedi V, Henderson AL, Giacomin PR, Guy C, Bankoti J et al. IL-35-mediated induction of a potent regulatory T cell population. Nat Immunol 2010; 11: 1093–1101.
Dorsey NJ, Chapoval SP, Smith EP, Skupsky J, Scott DW, Keegan AD . STAT6 controls the number of regulatory T cells in vivo, thereby regulating allergic lung inflammation. J Immunol 2013; 191: 1517–1528.
Acknowledgements
The authors declare that they have no conflicts of interest and acknowledge the financial support of grants from the National Health Research Institutes, National Science Council (101-2320-B-182-027-MY3), and Chang Gung Memorial Hospital (CMRPD3B0052 and BMRP440). CRS and WCY contributed equally to this work.
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Shen, CR., Yang, WC. & Chen, HW. The fate of regulatory T cells: survival or apoptosis. Cell Mol Immunol 11, 11–13 (2014). https://doi.org/10.1038/cmi.2013.49
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DOI: https://doi.org/10.1038/cmi.2013.49