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Preferential depletion of CD2low plasmacytoid dendritic cells in HIV-infected subjects

Cellular & Molecular Immunology volume 8, pages 441–444 (2011)Cite this article

Abstract

Plasmacytoid dendritic cells (pDCs) are decreased in number and are functionally impaired in HIV act reasons for pDCs depletion are still unknown. It was recently reported that pDCs can be divided into two functionally distinct populations based on their CD2 expression level. To determine how the CD2high and CD2low populations are affected by HIV infection, we analyzed their frequencies in the peripheral blood of HIV-infected subjects and healthy controls. We found that the CD2low pDC subset was preferentially depleted in infected individuals. The frequency of CD2low pDCs correlated with the CD4+ T-cell count but not with the plasma viral load. This finding furthers our understanding of the causes and consequences of pDC depletion during HIV infection.

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Acknowledgements

This work was supported in part by grants from the National Natural Science Foundation of China 30872365 (LZ), the Beijing Municipal of Science and Technology Major Project D09050703590901 and the National Key Technologies R&D Program for the 11th Five-Year Plan 2008ZX10001-001 and 2008ZX10001-006 (HW).

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Author notes

  1. These authors contributed equally to this work.

  2. Dr H WuDr LG Zhang, Beijing You-An Hospital, Affiliated to the Capital Medical University, Beijing 100054, China. E-mail: wuhd@public.bta.net.cn

  3. Key Laboratory of Infection and Immunity, Institute of Biophysics, Chinese Academy of Sciences, 15 Da Tun Road, Chaoyang District, Beijing 100101, China. E-mail: liguozhang@ibp.ac.cn

Authors and Affiliations

  1. Key Laboratory of Infection and Immunity, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China

    Qiumei Du, Qiumei Du, Yanmei Jiao, Peishuang Du & Liguo Zhang

  2. Graduate University of Chinese Academy of Sciences, Beijing, China

    Qiumei Du

  3. Beijing You-An Hospital, Affiliated to the Capital Medical University, Beijing, China

    Yanmei Jiao, Wei Hua, Rui Wang, Feili Wei, Yunxia Ji & Hao Wu

  4. Department of Immunology, The University of Texas, M.D. Anderson Cancer Center, Houston, TX, USA

    Yong-Jun Liu

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Du, Q., Jiao, Y., Hua, W. et al. Preferential depletion of CD2low plasmacytoid dendritic cells in HIV-infected subjects. Cell Mol Immunol 8, 441–444 (2011). https://doi.org/10.1038/cmi.2011.9

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