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Proinflammatory IL-17 induces iBALT development

Cellular & Molecular Immunology volume 9, pages 101–102 (2012)Cite this article

The development of secondary lymphoid organs (SLOs) and tertiary lymphoid organs (TLOs) share many common mechanisms. Molecules of the tumor necrosis factor family, especially lymphotoxin, and the lymphoid homeostatic chemokines, such as CXCL13, CCL19 and CCL21, play important roles in the development of both SLOs and TLOs.1, 2, 3 This may be unsurprising given the common microarchitectural features of SLOs and TLOs.

However, the processes of SLO and TLO development differ markedly. Whereas SLOs are usually embryonically programmed in the lymphoid anlagen under steady state conditions, TLOs are often reprogrammed postnatally in non-lymphoid tissues under chronic inflammatory conditions. Given these temporal and spatial differences and the differences in microenvironmental influences, the cellular and molecular components involved in the development of TLOs and SLOs could differ considerably. Unraveling the distinct features of TLOs and SLOs and the mechanisms by which they are formed have become topics of great interest in the field.

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Authors and Affiliations

  1. Key Laboratory of Infection and Immunity, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China

    Mingzhao Zhu

  2. Department of Pathology and Committee on Immunology, The University of Chicago, Chicago, IL, USA

    Yangxin Fu

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  1. Mingzhao Zhu
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  2. Yangxin Fu
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Correspondence to Mingzhao Zhu or Yangxin Fu.

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Zhu, M., Fu, Y. Proinflammatory IL-17 induces iBALT development. Cell Mol Immunol 9, 101–102 (2012). https://doi.org/10.1038/cmi.2011.46

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