Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Mini Review
  • Published:

Celiac disease: a model disease for gene–environment interaction

Cellular & Molecular Immunology volume 8, pages 93–95 (2011)Cite this article

Abstract

Celiac sprue remains a model autoimmune disease for dissection of genetic and environmental influences on disease progression. The 2010 Congress of Autoimmunity included several key sessions devoted to genetics and environment. Several papers from these symposia were selected for in-depth discussion and publication. This issue is devoted to this theme. The goal is not to discuss genetic and environmental interactions, but rather to focus on key elements of diagnosis, the inflammatory response and the mechanisms of autoimmunity.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Anderson DM . History of celiac disease. J Am Diet Assoc 1959; 35: 1158–1162.

    CAS  PubMed  Google Scholar 

  2. Schuppan D, Junker Y, Barisani D . Celiac disease: from pathogenesis to novel therapies. Gastroenterology 2009; 137: 1912–1933.

    Article  CAS  PubMed  Google Scholar 

  3. Catassi C, Rätsch IM, Gandolfi L, Pratesi R, Fabiani E, El Asmar R et al. Why is coeliac disease endemic in the people of the Sahara? Lancet 1999; 354: 647–648.

    Article  CAS  Google Scholar 

  4. Marsh MN, Gluten, major histocompatibility complex, and the small intestine. A molecular and immunobiologic approach to the spectrum of gluten sensitivity (‘celiac sprue’). Gastroenterology 1992; 102: 330–354.

    Article  CAS  PubMed  Google Scholar 

  5. Jabri B, Sollid LM . Tissue-mediated control of immunopathology of coeliac disease. Nature Rev Immunol 2009; 9: 58–70.

    Article  Google Scholar 

  6. Vorobjova T, Uibo O, Heilman K, Rägo T, Honkanen J, Vaarala O et al. Increased FOXP3 expression in small-bowel mucosa of children with coeliac disease and type 1 diabetes mellitus. Scand J Gastroenterol 2009; 44: 422–430.

    Article  CAS  PubMed  Google Scholar 

  7. Lindfors K, Mäki M, Kaukinen K . Transglutaminase 2-targeted autoantibodies in celiac disease: pathogenetic players in addition to diagnostic tools? Autoimmune Rev 2010; 9: 744–749.

    Article  CAS  Google Scholar 

  8. Zhernakova A, Elbers CC, Ferwerda B, Romanos J, Trynka G, Dubois PC et al. Evolutionary and fuctional analysis of celiac risk loci reveals SH2B3 as a protective factor against bacterial infection. Am J Hum Gen 2010; 86: 970–977.

    Article  CAS  Google Scholar 

  9. Trynka G, Wijmenga C, van Heel DA . A genetic perspective on coeliac disease. Trends Mol Med 2010; 16: 537–550.

    Article  CAS  PubMed  Google Scholar 

  10. Plot L, Amital H, Barzilai O, Ram M, Nicola B, Shoenfeld Y . Infections may have a protective role in the etiopathogenesis of celiac disease. Ann NY Acad Sci 2009; 1173: 670–674.

    Article  CAS  PubMed  Google Scholar 

  11. Ou G, Hedberg M, Hörstedt P, Baranov V, Forsberg G, Drobni M et al. Proximal small intestinal microbiota and identification of rod-shaped bacteria associated with childhood celiac disease. Am J Gastroenterol 2009; 104: 3058–3067.

    Article  PubMed  Google Scholar 

  12. de Palma G, Cinova J, Stepankova R, Tuckova L, Sanz Y . Pivotal advance: Bifidobacteria and Gram-negative bacteria differentially influence immune responses in the proinflammatory milieu of celiac disease. J Leukoc Biol 2010; 87: 765–778.

    Article  CAS  PubMed  Google Scholar 

  13. Meresse B, Ripoche J, Heyman M, Cerf-Bensussan N . Celiac disease: from oral tolerance to intestinal inflammation, autoimmunity and lymphogenesis. Mucosal Immunol 2009; 2: 8–23.

    Article  CAS  PubMed  Google Scholar 

  14. Monteleone G, Pender SL, Alstead E, Hauer AC, Lionetti P, McKenzie C . Role of interferon alpha in promoting T helper cell type I responses in the small intestine in coeliac disease. Gut 2001; 48: 425–429.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Maiuri L, Ciacci C, Auricchio S, Brown V, Quarantino S, Londei M . Interleukin-15 mediates epithelial changes in celiac disease. Gastroenterology 2000; 119: 996–1006.

    Article  CAS  PubMed  Google Scholar 

  16. Stene LC, Honeyman MC, Hoffenberg EJ, Haas JE, Sokol RJ, Emery L et al. Rotavirus infection frequency and risk of celiac disease autoimmunity in early childhood: a longitudinal study. Am J Gastroenterol 2006; 101: 2333–2340.

    Article  CAS  PubMed  Google Scholar 

  17. Lammers KM, Lu R, Brownley J, Lu B, Gerard C, Thomas K et al. Gliadin induces an increase in intestinal permeability and zonulin release by binding to chemokine receptor CXCR3. Gastroenterology 2008; 135: 194–204.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  18. Visser J, Rozing J, Sapone A, Lammers K, Fasano A . Tight junctions, intestinal permeability, and autoimmunity. Celiac disease and type 1 diabetes paradigms. Ann NY Acad Sci 2009; 1165: 195–205.

    Article  CAS  PubMed  Google Scholar 

  19. Stamnaes J, Dorum S, Fleckenstein B, Aeshlimann D, Solid LM . Gluten T cell epitope targeting by TG3 and TG6; implications for dermatitis herpetiformis and gluten ataxia. Amino Acids 2010; 39: 1183–1191.

    Article  CAS  PubMed  Google Scholar 

  20. Simpson M, Mojibian M, Barriga K, Scott FW, Fasano A, Rewers M et al. An exploration of Glo-3A antibdy levels in children at increased risk for type 1 diabetes. Pediatr Diabetes 2009; 10: 563–572.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  21. Arnson Y, Shoenfeld Y, Amital H . Effects of tobacco smoke on immunity, inflammation and autoimmunity. J Autoimmun 2010; 34: J258–J265.

    Article  CAS  PubMed  Google Scholar 

  22. Berkun Y, Padeh S . Environmental factors and the geoepidemiology of juvenile idiopathic arthritis. Autoimmun Rev 2010; 9: A319–A324.

    Article  PubMed  Google Scholar 

  23. Bhat A, Naguwa S, Cheema G, Gershwin ME . The epidemiology of transverse myelitis. Autoimmun Rev 2010; 9: A395–A399.

    Article  PubMed  Google Scholar 

  24. Biggioggero M, Meroni PL . The geoepidemiology of the antiphospholipid antibody syndrome. Autoimmun Rev 2010; 9: A299–A304.

    Article  PubMed  Google Scholar 

  25. Borchers AT, Naguwa SM, Keen CL, Gershwin ME . The implications of autoimmunity and pregnancy. J Autoimmun 2010; 34: J287–J299.

    Article  CAS  PubMed  Google Scholar 

  26. Borchers AT, Naguwa SM, Shoenfeld Y, Gershwin ME . The geoepidemiology of systemic lupus erythematosus. Autoimmun Rev 2010; 9: A277–A287.

    Article  CAS  PubMed  Google Scholar 

  27. Borchers AT, Uibo R, Gershwin ME . The geoepidemiology of type 1 diabetes. Autoimmun Rev 2010; 9: A355–A365.

    Article  PubMed  Google Scholar 

  28. Brooks WH, Le Dantec C, Pers JO, Youinou P, Renaudineau Y . Epigenetics and autoimmunity. J Autoimmun 2010; 34: J207–J219.

    Article  CAS  PubMed  Google Scholar 

  29. Chandran V, Raychaudhuri SP . Geoepidemiology and environmental factors of psoriasis and psoriatic arthritis. J Autoimmun 2010; 34: J314–J321.

    Article  CAS  PubMed  Google Scholar 

  30. Chang C . The immune effects of naturally occurring and synthetic nanoparticles. J Autoimmun 2010; 34: J234–J246.

    Article  CAS  PubMed  Google Scholar 

  31. Chang C, Gershwin ME . Drugs and autoimmunity—a contemporary review and mechanistic approach. J Autoimmun 2010; 34: J266–J275.

    Article  CAS  PubMed  Google Scholar 

  32. Chen M, Daha MR, Kallenberg CG . The complement system in systemic autoimmune disease. J Autoimmun 2010; 34: J276–J286.

    Article  CAS  PubMed  Google Scholar 

  33. Chen M, Kallenberg CG . The environment, geoepidemiology and ANCA-associated vasculitides. Autoimmun Rev 2010; 9: A293–A298.

    Article  CAS  PubMed  Google Scholar 

  34. Deane S, Teuber SS, Gershwin ME . The geoepidemiology of immune thrombocytopenic purpura. Autoimmun Rev 2010; 9: A342–A349.

    Article  PubMed  Google Scholar 

  35. Ehrenfeld M . Geoepidemiology: the environment and spondyloarthropathies. Autoimmun Rev 2010; 9: A325–A329.

    Article  PubMed  Google Scholar 

  36. Hemminki K, Li X, Sundquist J, Sundquist K . The epidemiology of Graves' disease: evidence of a genetic and an environmental contribution. J Autoimmun 2010; 34: J307–J313.

    Article  CAS  PubMed  Google Scholar 

  37. Hoffmann MH, Trembleau S, Muller S, Steiner G . Nucleic acid-associated autoantigens: pathogenic involvement and therapeutic potential. J Autoimmun 2010; 34: J178–J206.

    Article  CAS  PubMed  Google Scholar 

  38. Invernizzi P . Geoepidemiology of autoimmune liver diseases. J Autoimmun 2010; 34: J300–J306.

    Article  CAS  PubMed  Google Scholar 

  39. Lambert JF, Nydegger UE . Geoepidemiology of autoimmune hemolytic anemia. Autoimmun Rev 2010; 9: A350–A354.

    Article  CAS  PubMed  Google Scholar 

  40. Leung PS, Shu SA, Kenny TP, Wu PY, Tao MH . Development and validation of gene therapies in autoimmune diseases: epidemiology to animal models. Autoimmun Rev 2010; 9: A400–A405.

    Article  CAS  PubMed  Google Scholar 

  41. Lleo A, Invernizzi P, Gao B, Podda M, Gershwin ME . Definition of human autoimmunity–autoantibodies versus autoimmune disease. Autoimmun Rev 2010; 9: A259–A266.

    Article  CAS  PubMed  Google Scholar 

  42. Logan I, Bowlus CL . The geoepidemiology of autoimmune intestinal diseases. Autoimmun Rev 2010; 9: A372–A378.

    Article  PubMed  Google Scholar 

  43. Mackay IR . Travels and travails of autoimmunity: a historical journey from discovery to rediscovery. Autoimmun Rev 2010; 9: A251–A258.

    Article  CAS  PubMed  Google Scholar 

  44. Maverakis E, Miyamura Y, Bowen MP, Correa G, Ono Y, Goodarzi H . Light, including ultraviolet. J Autoimmun 2010; 34: J247–J257.

    Article  CAS  PubMed  Google Scholar 

  45. Mavragani CP, Moutsopoulos HM . The geoepidemiology of Sjogren's syndrome. Autoimmun Rev 2010; 9: A305–A310.

    Article  PubMed  Google Scholar 

  46. Meyer A, Levy Y . Chapter 33: geoepidemiology of myasthenia gravis. Autoimmun Rev 2010; 9: A383–A386.

    Article  PubMed  Google Scholar 

  47. Meyer N, Misery L . Geoepidemiologic considerations of auto-immune pemphigus. Autoimmun Rev 2010; 9: A379–A382.

    Article  CAS  PubMed  Google Scholar 

  48. Milo R, Kahana E . Multiple sclerosis: geoepidemiology, genetics and the environment. Autoimmun Rev 2010; 9: A387–A394.

    Article  CAS  PubMed  Google Scholar 

  49. Powell JJ, Faria N, Thomas-McKay E, Pele LC . Origin and fate of dietary nanoparticles and microparticles in the gastrointestinal tract. J Autoimmun 2010; 34: J226–J233.

    Article  CAS  PubMed  Google Scholar 

  50. Prieto S, Grau JM . The geoepidemiology of autoimmune muscle disease. Autoimmun Rev 2010; 9: A330–A334.

    Article  PubMed  Google Scholar 

  51. Ranque B, Mouthon L . Geoepidemiology of systemic sclerosis. Autoimmun Rev 2010; 9: A311–A318.

    Article  PubMed  Google Scholar 

  52. Round JL, O'Connell RM, Mazmanian SK . Coordination of tolerogenic immune responses by the commensal microbiota. J Autoimmun 2010; 34: J220–J225.

    Article  CAS  PubMed  Google Scholar 

  53. Sands J, Tuscano JM . Geoepidemiology and autoimmune manifestations of lymphoproliferative disorders. Autoimmun Rev 2010; 9: A335–A341.

    Article  PubMed  Google Scholar 

  54. Segelmark M, Hellmark T . Autoimmune kidney diseases. Autoimmun Rev 2010; 9: A366–A371.

    Article  CAS  PubMed  Google Scholar 

  55. Selmi C . The worldwide gradient of autoimmune conditions. Autoimmun Rev 2010; 9: A247–A250.

    Article  PubMed  Google Scholar 

  56. Selmi C, Tsuneyama K . Nutrition, geoepidemiology, and autoimmunity. Autoimmun Rev 2010; 9: A267–A270.

    Article  CAS  PubMed  Google Scholar 

  57. Shapira Y, Agmon-Levin N, Shoenfeld Y . Defining and analyzing geoepidemiology and human autoimmunity. J Autoimmun 2010; 34: J168–J177.

    Article  CAS  PubMed  Google Scholar 

  58. Stojanovich L . Stress and autoimmunity. Autoimmun Rev 2010; 9: A271–A276.

    Article  CAS  PubMed  Google Scholar 

  59. Tobon GJ, Youinou P, Saraux A . The environment, geo-epidemiology, and autoimmune disease: rheumatoid arthritis. Autoimmun Rev 2010; 9: A288–A292.

    Article  CAS  PubMed  Google Scholar 

  60. Tomer Y . Hepatitis C and interferon induced thyroiditis. J Autoimmun 2010; 34: J322–J326.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  61. Youinou P, Pers JO, Gershwin ME, Shoenfeld Y . Geo-epidemiology and autoimmunity. J Autoimmun 2010; 34: J163–J167.

    Article  CAS  PubMed  Google Scholar 

  62. Zeki AA, Schivo M, Chan AL, Hardin KA, Kenyon NJ, Albertson TE, et al. Geoepidemiology of COPD and idiopathic pulmonary fibrosis. J Autoimmun 2010; 34: J327–J338.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Immunology Group, IGMP, University of Tartu, Ravila 19, Tartu, Estonia

    Raivo Uibo

  2. University of Science and Technology of China, Hefei, China

    Zhigang Tian

  3. Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis School of Medicine, Davis, CA, USA

    M Eric Gershwin

Authors
  1. Raivo Uibo
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Zhigang Tian
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. M Eric Gershwin
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to M Eric Gershwin.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Uibo, R., Tian, Z. & Gershwin, M. Celiac disease: a model disease for gene–environment interaction. Cell Mol Immunol 8, 93–95 (2011). https://doi.org/10.1038/cmi.2010.62

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/cmi.2010.62

Keywords

This article is cited by

Search

Advanced search

Quick links