Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Brief Report
  • Published:

Plasma Levels of Monocyte Chemotactic Protein 3 and Beta-Nerve Growth Factor Increase with Amnestic Mild Cognitive Impairment

Cellular & Molecular Immunology volume 6, pages 143–147 (2009)Cite this article

Abstract

A number of studies have investigated peripheral inflammatory indices, including plasma cytokines and related molecules according to subtypes of dementia, but not in mild cognitive impairment (MCI). In this study, we used multiplex cytokine assay to assess the plasma levels of 22 cytokines in patients with MCI subtyped as amnestic and non-amnestic, according to cognitive features. When comparing the levels of plasma growth factors, chemokines and cytokines, plasma levels of monocyte chemotactic protein 3 (MCP-3), and beta-nerve growth factor (β-NGF) in these two groups, they were found to be significantly higher in amnestic MCI patients than in non-amnestic MCI patients, after adjusting for age and gender. This suggests that plasma MCP-3 and β-NGF may be useful in differentiating subtypes of MCI.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

Author information

Authors and Affiliations

  1. Department of Psychiatry, Yonsei University College of Medicine, Seoul, Korea

    Kang Soo Lee & Byoung Hoon Oh

  2. Institution of Behavioral Science in Medicine, Yonsei University College of Medicine, Seoul, Korea

    Kang Soo Lee & Byoung Hoon Oh

  3. Yonsei University Research Institute of Science for Aging, Yonsei University, Seoul, Korea

    Ji Hyung Chung & Kyung Hye Lee

  4. Department of Food and Nutrition, College of Health Science, Korea University, Seoul, Korea

    Min-Jeong Shin

  5. Department of Family Medicine, Seoul Medical Center, Seoul, Korea

    Soo Hyung Lee

  6. Department of Psychiatry, Ajou University School of Medicine, Suwon, Korea

    Chang Hyung Hong

  7. Memory Impairment Center, Ajou University Hospital, Suwon, Korea

    Chang Hyung Hong

Authors
  1. Kang Soo Lee
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Ji Hyung Chung
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Kyung Hye Lee
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Min-Jeong Shin
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Byoung Hoon Oh
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Soo Hyung Lee
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Chang Hyung Hong
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Chang Hyung Hong.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Lee, K., Chung, J., Lee, K. et al. Plasma Levels of Monocyte Chemotactic Protein 3 and Beta-Nerve Growth Factor Increase with Amnestic Mild Cognitive Impairment. Cell Mol Immunol 6, 143–147 (2009). https://doi.org/10.1038/cmi.2009.20

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1038/cmi.2009.20

Keywords

Search

Advanced search

Quick links