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Skin allograft for severe chronic GvHD

Bone Marrow Transplantation volume 52, pages 1060–1062 (2017)Cite this article

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We describe here the favorable clinical evolution of a severe, chronic GvHD treated in 2009 with a skin allograft, obtained from the same allogeneic hematopoietic stem cell donor, in a young patient with acute leukemia. Sustained immunological tolerance between the donor and patient skin had been obtained in the context of a full-donor hematopoietic chimerism; the latter allowed for the permanent discontinuation of any systemic immunosuppression, suggesting that full-donor hematopoietic chimerism might underlie the immunological tolerance of transplanted tissues or organs.

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Acknowledgements

We thank all personnel at the Department of Hematology of Lyon-Sud Hospital (Pierre Bénite, Lyon, France) and at the Department of Plastic Surgery of Croix Rousse Hospital (Lyon, France) for their remarkable contribution in patient’s care and assistance to her family.

Author contributions

RC conceived the treatment and wrote the manuscript; VD performed the chimerism analyses; F-EN, SD-L, HL, CA, AM, OD and FB provided clinical care; MS provided technical assistance; FC revised and commented on the manuscript; MM provided clinical care, followed the patient and supervised the manuscript.

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Authors and Affiliations

  1. Department of Hematology, Lyon-Sud Hospital, Hospices Civils de Lyon, Pierre Bénite, Lyon, France

    R Crocchiolo, F-E Nicolini, M Sobh, S Ducastelle-Lepretre, H Labussiere, L Lebras & M Michallet

  2. Histocompatibility Laboratory and HLA typing, Etablissement Francais du Sang, Lyon, France

    V Dubois

  3. Banque de Tissus et de Cellules, Edouard Herriot Hospital, Lyon, France

    C Auxenfans & O Damour

  4. Plastic Surgery Department, Croix Rousse Hospital, Lyon, France

    A Mojallal & F Braye

Authors
  1. R Crocchiolo
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  2. V Dubois
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  4. M Sobh
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  5. S Ducastelle-Lepretre
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  7. L Lebras
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  8. C Auxenfans
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  9. A Mojallal
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  10. O Damour
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  12. M Michallet
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Corresponding author

Correspondence to R Crocchiolo.

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Competing interests

RC is an employee of MolMed SpA at the time of submission. The remaining authors declare no conflict of interest.

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Crocchiolo, R., Dubois, V., Nicolini, FE. et al. Skin allograft for severe chronic GvHD. Bone Marrow Transplant 52, 1060–1062 (2017). https://doi.org/10.1038/bmt.2017.53

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