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MALDI-TOF MS in post-transplant bloodstream infections: reliable identification of causative bacteria in the neutropenic phase

Bone Marrow Transplantation volume 52, pages 778–780 (2017)Cite this article

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Bloodstream infection (BSI) is a frequent and life-threatening complication in patients undergoing allogeneic hematopoietic stem cell transplantation (allo-SCT) and rapid identification of pathogens is critical.1, 2 Pre-engraftment BSI is also a risk factor for acute GvHD,3 delayed neutrophil recovery,4 and non-relapse-mortality5, 6 after allo-SCT. Rapid identification of the causative bacteria in BSI is critical in order to improve the transplant outcome.

Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) has been widely used for the identification of bacterial and fungal species in culture specimens. It identifies bacterial genus and species by profiling of bacterial ribosomal proteins.7, 8 However, usefulness of MALDI-TOF MS in BSI during allo-SCT remains to be investigated.

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Acknowledgements

We thank to Francis Shand for proofreading and Hiroaki Iijima (Clinical Research and Medical innovation center, Hokkaido University Hospital) for helping biostatistics analysis. This work was supported in part by grants provided by the North Japan Hematology Study Group (NJHSG), Sapporo, Hokkaido, Japan and research grants from Astellas Foundation for Research on Metabolic Disorders (DH) and AMED: Japan Agency for Medical Research and Development (16ek05110012h0002, TT).

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Authors and Affiliations

  1. Department of Hematology, Hokkaido University Graduate School of Medicine, Sapporo, Japan

    M Kanaya, D Hashimoto, T Endo, J Sugita, H Ohigashi, J Hashiguchi, T Matsukawa, S Matsuoka, M Kosugi-Kanaya, H Goto, M Onozawa, K Kahata, K Fujimoto, T Kondo & T Teshima

  2. Division of Laboratory and Transfusion Medicine, Hokkaido University Hospital, Sapporo, Japan

    Y Hayashi, M Kosugi-Kanaya, K Kahata, K Akizawa, H Shibuya & C Shimizu

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  1. M Kanaya
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  19. T Teshima
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Correspondence to M Kanaya.

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Kanaya, M., Hayashi, Y., Hashimoto, D. et al. MALDI-TOF MS in post-transplant bloodstream infections: reliable identification of causative bacteria in the neutropenic phase. Bone Marrow Transplant 52, 778–780 (2017). https://doi.org/10.1038/bmt.2016.365

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