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Clinical management of genital chronic GvHD

Bone Marrow Transplantation volume 52, pages 803–810 (2017)Cite this article

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Abstract

Chronic GvHD (cGvHD) of the genital tract is an underreported and infrequently recognized complication of allogeneic hematopoietic cell transplantation in both male and female long-term survivors. Its pathophysiology, clinical manifestations and management are not well understood, and studies are limited. We thus provide a comprehensive review of genital cGvHD in both men and women, as well as discuss related issues of sexual health and viral reactivation. We further provide guidance on screening, management and long-term follow-up, as well as future priority areas of study.

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Acknowledgements

This paper was funded in part by the Intramural Program of the National Institutes of Health and the National Institute of Child Health and Human Development.

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Authors and Affiliations

  1. Blood & Marrow Transplant Program, Hematology and Medical Oncology, Cleveland Clinic, Taussig Cancer Institute, Cleveland, OH, USA

    B K Hamilton & N S Majhail

  2. Obstetrics and Gynecology, Cleveland Clinic, Cleveland, OH, USA

    O Goje

  3. Division of Hematology/Oncology, Vanderbilt University Medical Center, Nashville, TN, USA

    B N Savani

  4. Office of the Clinical Director, Intramural Program, National Institutes of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA

    P Stratton

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  1. B K Hamilton
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Correspondence to B K Hamilton.

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Hamilton, B., Goje, O., Savani, B. et al. Clinical management of genital chronic GvHD. Bone Marrow Transplant 52, 803–810 (2017). https://doi.org/10.1038/bmt.2016.315

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