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Lymphoma

Allogeneic stem cell transplantation for patients with mantle cell lymphoma who failed autologous stem cell transplantation: a national survey of the SFGM-TC

Bone Marrow Transplantation volume 51, pages 1184–1190 (2016)Cite this article

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Abstract

Poly-chemotherapy plus rituximab followed by autologous stem cell transplantation (auto-SCT) is standard care for untreated young patients with mantle cell lymphoma (MCL). Despite this intensive treatment, transplant patients remain highly susceptible to relapse over time. The French SFGM-TC performed a national survey on reduced-intensity conditioning allogeneic stem cell transplantation (RIC-allo-SCT) for fit relapsed/refractory patients who failed after auto-SCT (n=106). Median times of relapse after auto-SCT, and from auto-SCT to RIC-allo-SCT were 28 months and 3.6 years, respectively. Sixty per cent of patients received at least three lines of treatment before RIC-allo-SCT. Conditioning regimens for RIC-allo-SCT were heterogeneous. Twenty patients experienced grade III/IV aGvHD, extensive cGvHD was reported in 28 cases. Median follow-up after RIC-allo-SCT was 45 months. Median PFS after RIC-allo-SCT was 30.1 months and median overall survival was 62 months. Treatment-related mortality (TRM) at 1 year and 3 years were estimated at 28% and 32%, respectively. A total of 52 patients died; major causes of death were related to toxicity (n=34) and MCL (n=11). Patients in good response before RIC-allo-SCT experienced a better PFS and OS. Our work highlights the need for new RIC-allo-SCT MCL-tailored approaches to reduce TRM, and early and late relapse.

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Authors and Affiliations

  1. Department of Hematology, University Hospital, Nantes, France

    B Tessoulin, P Chevallier & S Le Gouill

  2. INSERM team 10 UMR 892, CRCNA, Nantes, France

    B Tessoulin & S Le Gouill

  3. Department of Hematology, University Hospital, Montpellier, France

    P Ceballos

  4. Department of Hematology, Paoli Calmettes, Marseille, France

    D Blaise

  5. Department of Hematology, University Hospital, Clermont-Ferrand, France

    O Tournilhac

  6. Department of Hematology, University Hospital, Lille, France

    J Gauthier

  7. Department of Hematology, University Hospital, Poitiers, France

    N Maillard

  8. Department of Hematology, University Hospital, Bordeaux, France

    R Tabrizi

  9. Department of Hematology, Pitie Salpetriere, Paris, France

    S Choquet

  10. Department of Hematology, University Hospital, Grenoble, France

    S Carras

  11. Department of Hematology, University Hospital, Angers, France

    N Ifrah

  12. Department of Hematology, University Hospital, Brest, France

    G Guillerm

  13. Department of Hematology, University Hospital-Saint Antoine, Paris, France

    M Mohty

  14. Department of Hematology, Centre Henri-Becquerel, Rouen, France

    H Tilly

  15. Department of Hematology, Saint Louis Hospital, Paris, France

    G Socie

  16. Department of Hematology, Institut de Cancerologie de la Loire, Saint Etienne, France

    J Cornillon

  17. Department of Hematology, Necker Hospital, Paris, France

    O Hermine

  18. Department of Hematology, University Hospital, Besancon, France

    É Daguindau

  19. Department of Hematology, University hospital, Lyon, France

    E Bachy

  20. Department of Hematology, University Hospital, Limoges, France

    S Girault

  21. Department of Hematology, University Hospital, Rennes, France

    T Marchand

  22. University Cancer Institute, Toulouse, France

    L Oberic

  23. Department of Hematology, University Hospital, Caen, France

    O Reman

  24. Department of Epidemiology, University Hospital of Nantes, Nantes, France

    C Leux

  25. Centre d’Investigation Clinique en Cancérologie (CI2C), CHU de Nantes, Nantes, France

    S Le Gouill

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  1. B Tessoulin
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  14. H Tilly
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  15. G Socie
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  16. J Cornillon
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  17. O Hermine
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  18. É Daguindau
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  20. S Girault
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  24. C Leux
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Correspondence to S Le Gouill.

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Tessoulin, B., Ceballos, P., Chevallier, P. et al. Allogeneic stem cell transplantation for patients with mantle cell lymphoma who failed autologous stem cell transplantation: a national survey of the SFGM-TC. Bone Marrow Transplant 51, 1184–1190 (2016). https://doi.org/10.1038/bmt.2016.102

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