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Left ventricular mass and ambulatory blood pressure are increased in long-term survivors of childhood cancer after autologous SCT

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References

  1. Kero AE, Jarvela LS, Arola M, Malila N, Madanat-Harjuoja LM, Matomaki J et al. Late mortality among 5-year survivors of early onset cancer: a population-based register study. Int J Cancer 2015; 136: 1655–1664.

    Article  CAS  Google Scholar 

  2. Lipshultz SE, Colan SD, Gelber RD, Perez-Atayde AR, Sallan SE, Sanders SP . Late cardiac effects of doxorubicin therapy for acute lymphoblastic leukemia in childhood. N Engl J Med 1991; 324: 808–815.

    Article  CAS  Google Scholar 

  3. Lipshultz SE, Adams MJ, Colan SD, Constine LS, Herman EH, Hsu DT et al. Long-term cardiovascular toxicity in children, adolescents, and young adults who receive cancer therapy: pathophysiology, course, monitoring, management, prevention, and research directions: a scientific statement from the American Heart Association. Circulation 2013; 128: 1927–1995.

    Article  Google Scholar 

  4. Berry JD, Dyer A, Cai X, Garside DB, Ning H, Thomas A et al. Lifetime risks of cardiovascular disease. N Engl J Med 2012; 366: 321–329.

    Article  CAS  Google Scholar 

  5. Armenian SH, Hudson MM, Mulder RL, Chen MH, Constine LS, Dwyer M et al. Recommendations for cardiomyopathy surveillance for survivors of childhood cancer: a report from the International Late Effects of Childhood Cancer Guideline Harmonization Group. Lancet Oncol 2015; 16: e123–e136.

    Article  Google Scholar 

  6. Plana JC, Galderisi M, Barac A, Ewer MS, Ky B, Scherrer-Crosbie M et al. Expert consensus for multimodality imaging evaluation of adult patients during and after cancer therapy: a report from the American Society of Echocardiography and the European Association of Cardiovascular Imaging. Eur Heart J Cardiovasc Imaging 2014; 15: 1063–1093.

    Article  Google Scholar 

  7. Hunt SA, Abraham WT, Chin MH, Feldman AM, Francis GS, Ganiats TG et al. 2009 focused update incorporated into the ACC/AHA 2005 Guidelines for the Diagnosis and Management of Heart Failure in Adults: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines: developed in collaboration with the International Society for Heart and Lung Transplantation. Circulation 2009; 119: e391–e479.

    PubMed  Google Scholar 

  8. Vatanen A, Sarkola T, Ojala TH, Turanlahti M, Jahnukainen T, Saarinen-Pihkala UM et al. Radiotherapy-related arterial intima thickening and plaque formation in childhood cancer survivors detected with very-high resolution ultrasound during young adulthood. Pediatr Blood Cancer 2015; 62: 2000–2006.

    Article  CAS  Google Scholar 

  9. Saarinen-Pihkala UM, Hovi L, Koivusalo A, Jahnukainen K, Karikoski R, Sariola H et al. Thiotepa and melphalan based single, tandem, and triple high dose therapy and autologous stem cell transplantation for high risk neuroblastoma. Pediatr Blood Cancer 2012; 59: 1190–1197.

    Article  Google Scholar 

  10. Ojala T, Mathur S, Vatanen A, Sinha MD, Jahnukainen K, Simpson J . Repeatability and agreement of real time three-dimensional echocardiography measurements of left ventricular mass and synchrony in young patients. Echocardiography 2015; 32: 522–527.

    Article  Google Scholar 

  11. Hovi L, Kurimo M, Taskinen M, Vettenranta J, Vettenranta K, Saarinen-Pihkala UM . Suboptimal long-term physical performance in children and young adults after pediatric allo-SCT. Bone Marrow Transplant 2010; 45: 738–745.

    Article  CAS  Google Scholar 

  12. Lipshultz SE, Adams MJ . Cardiotoxicity after childhood cancer: beginning with the end in mind. J Clin Oncol 2010; 28: 1276–1281.

    Article  Google Scholar 

  13. Alehan D, Sahin M, Varan A, Yildirim I, Kupeli S, Buyukpamukcu M . Tissue Doppler evaluation of systolic and diastolic cardiac functions in long-term survivors of Hodgkin lymphoma. Pediatr Blood Cancer 2012; 58: 250–255.

    Article  Google Scholar 

  14. Adams MJ, Lipshultz SE . Pathophysiology of anthracycline- and radiation-associated cardiomyopathies: implications for screening and prevention. Pediatr Blood Cancer 2005; 44: 600–606.

    Article  Google Scholar 

  15. Braunwald E . Biomarkers in heart failure. N Engl J Med 2008; 358: 2148–2159.

    Article  CAS  Google Scholar 

  16. King DE, Everett CJ, Mainous AG 3rd, Liszka HA . Long-term prognostic value of resting heart rate in subjects with prehypertension. Am J Hypertens 2006; 19: 796–800.

    Article  Google Scholar 

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Acknowledgements

We thank Drs Päivi Lähteenmäki, Merja Möttönen, Pekka Riikonen and Katriina Parto for identifying the NBL long-term survivors in local hospital records and Pt Marita Kurimo for performing the physical performance tests.

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Correspondence to A Vatanen.

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The authors declare no conflict of interest.

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Supplementary Information accompanies this paper on Bone Marrow Transplantation website

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Vatanen, A., Ojala, T., Sarkola, T. et al. Left ventricular mass and ambulatory blood pressure are increased in long-term survivors of childhood cancer after autologous SCT. Bone Marrow Transplant 51, 853–855 (2016). https://doi.org/10.1038/bmt.2015.355

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