Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Original Article
  • Published:

Infections

Infections by carbapenem-resistant Klebsiella pneumoniae in SCT recipients: a nationwide retrospective survey from Italy

Bone Marrow Transplantation volume 50, pages 282–288 (2015)Cite this article

Subjects

Abstract

Infections by carbapenem-resistant Klebsiella pneumoniae (CRKp) represent a challenging problem after SCT. A retrospective survey (January 2010 to July 2013) involving 52 Italian centers was performed to assess the epidemiology and the prognostic factors of CRKp infections in auto- and allo-SCT. Cases of CRKp infection were reported in 53.4% of centers. CRKp infections were documented in 25 auto-SCTs and 87 allo-SCTs, with an incidence of 0.4% (from 0.1% in 2010 to 0.7% in 2013) and 2% (from 0.4% in 2010 to 2.9% in 2013), respectively. A CRKp colonization documented before or after transplant was followed by an infection in 25.8% of auto-SCT and 39.2% of allo-SCT patients. The infection-related mortality rates were 16% and 64.4%, respectively. A pre-transplant CRKp infection (hazard ratio (HR) 0.33, 95% confidence intervals (CIs) 0.15–0.74; P=0.007) and a not CRKp-targeted first-line treatment (HR 2.67, 95% CI 1.43–4.99; P=0.002) were independent factors associated with an increased mortality in allo-SCT patients who developed a CRKp infection. Our study shows challenging findings of CRKp infections in SCT patients in Italy particularly after allo-SCT. The detection of carriers and the definition of early therapeutic strategies represent critical aspects of the management of CRKp infections after SCT.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1
Figure 2
Figure 3

Similar content being viewed by others

References

  1. Munoz-Price LS, Poirel L, Bonomo RA, Schwaber MJ, Daikos GL, Cormican M et al. Clinical epidemiology of the global expansion of Klebsiella pneumoniae carbapenemases. Lancet Infect Dis. 2013; 13: 785–796.

    Article  Google Scholar 

  2. Tzouvelekis LS, Markogiannakis A, Psichogiou M, Tassios PT, Daikos GL . Carbapenemases in Klebsiella pneumoniae and other Enterobacteriaceae: an evolving crisis of global dimensions. Clin Microbiol Rev 2012; 25: 682–707.

    Article  CAS  Google Scholar 

  3. Cantón R, Akóva M, Carmeli Y, Giske CG, Glupczynski Y, Gniadkowski M et al. Rapid evolution and spread of carbapenemases among Enterobacteriaceae in Europe. Clin Microbiol Infect 2012; 18: 413–431.

    Article  Google Scholar 

  4. Giani T, D'Andrea MM, Pecile P, Borgianni L, Nicoletti P, Tonelli F et al. Emergence in Italy of Klebsiella pneumoniae sequence type 258 producing KPC-3 carbapenemase. J Clin Microbiol 2009; 47: 3793–3794.

    Article  Google Scholar 

  5. Fontana C, Favaro M, Sarmati L, Natoli S, Altieri A, Bossa MC et al. Emergence of KPC-producing Klebsiella pneumoniae in Italy. BMC Res Notes 2010; 3: 40.

    Article  Google Scholar 

  6. Gaibani P, Ambretti S, Berlingeri A, Gelsomino F, Bielli A, Landini MP et al. Rapid increase of carbapenemase-producing Klebsiella pneumoniae strains in a large Italian hospital: surveillance period 1 March—30 September 2010. Euro Surveill 2011; 16.

  7. Giani T, Pini B, Arena F, Conte V, Bracco S, Migliavacca R et al. Epidemic diffusion of KPC carbapenemase-producing Klebsiella pneumoniae in Italy: results of the first countrywide survey, 15 May to 30 June 2011. Euro Surveill 2013; 18.

  8. Mammina C, Bonura C, Di Bernardo F, Aleo A, Fasciana T, Sodano C et al. Ongoing spread of colistin-resistant Klebsiella pneumoniae in different wards of an acute general hospital, Italy, June to December 2011. Euro Surveill 2012; 17.

  9. Tumbarello M, Viale P, Viscoli C, Trecarichi EM, Tumietto F, Marchese A et al. Predictors of mortality in bloodstream infections caused by Klebsiella pneumoniae carbapenemase-producing K. pneumoniae: importance of combination therapy. Clin Infect Dis 2012; 55: 943–950.

    Article  CAS  Google Scholar 

  10. Zarkotou O, Pournaras S, Tselioti P, Dragoumanos V, Pitiriga V, Ranellou K et al. A. Predictors of mortality in patients with bloodstream infections caused by KPC-producing Klebsiella pneumoniae and impact of appropriate antimicrobial treatment. Clin Microbiol Infect 2011; 17: 1798–1803.

    Article  CAS  Google Scholar 

  11. Bergamasco MD, Barroso Barbosa M, de Oliveira Garcia D, Cipullo R, Moreira JC, Baia C et al. Infection with Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae in solid organ transplantation. Transpl Infect Dis 2012; 14: 198–205.

    Article  CAS  Google Scholar 

  12. Taglietti F, Di Bella S, Galati V, Topino S, Iappelli M, Petrosillo N . Carbapenemase-producing Klebsiella pneumoniae-related mortality among solid organ-transplanted patients: do we know enough? Transpl Infect Dis 2013; 15: E164–E165.

    Article  CAS  Google Scholar 

  13. Kalpoe JS, Sonnenberg E, Factor SH, del Rio Martin J, Schiano T, Patel G et al. Mortality associated with carbapenem-resistant Klebsiella pneumoniae infections in liver transplant recipients. Liver Transpl 2012; 18: 468–474.

    Article  Google Scholar 

  14. Clancy CJ, Chen L, Shields RK, Zhao Y, Cheng S, Chavda KD et al. Epidemiology and molecular characterization of bacteremia due to carbapenem-resistant Klebsiella pneumoniae in transplant recipients. Am J Transplant 2013; 13: 2619–2633.

    Article  CAS  Google Scholar 

  15. Satlin MJ, Jenkins SG, Walsh TJ . The global challenge of carbapenem-resistant enterobacteriaceae in transplant recipients and patients with hematologic malignancies. Clin Infect Dis 2014; 58: 1274–1283.

    Article  Google Scholar 

  16. Gupta N, Limbago BM, Patel JB, Kallen AJ . Carbapenem-resistant Enterobacteriaceae: epidemiology and prevention. Clin Infect Dis 2011; 53: 60–67.

    Article  Google Scholar 

  17. Zuckerman T, Benyamini N, Sprecher H, Fineman R, Finkelstein R, Rowe JM et al. SCT in patients with carbapenem resistant Klebsiella pneumoniae: a single center experience with oral gentamicin for the eradication of carrier state. Bone Marrow Transplant 2011; 46: 1226–1230.

    Article  CAS  Google Scholar 

  18. Satlin MJ, Calfee DP, Chen L, Fauntleroy KA, Wilson SJ, Jenkins SG et al. Emergence of carbapenem-resistant Enterobacteriaceae as causes of bloodstream infections in patients with hematologic malignancies. Leuk Lymphoma 2013; 54: 799–806.

    Article  CAS  Google Scholar 

  19. Russell JA . Management of sepsis. N Engl J Med 2006; 355: 1699–1713.

    Article  CAS  Google Scholar 

  20. Girmenia C, Raiola AM, Piciocchi A, Algarotti A, Stanzani M, Cudillo L et al. Incidence and outcome of invasive fungal diseases after allogeneic stem cell transplantation: a prospective study of the Gruppo Italiano Trapianto Midollo Osseo(GITMO). Biol Blood Marrow Transplant. 2014; 20: 872–880.

    Article  Google Scholar 

  21. European Centre for Disease Prevention and Control (ECDC). Antimicrobial resistance surveillance in Europe 2012. Annual Report of the European Antimicrobial Resistance Surveillance Network (EARS-Net). ECDC: Stockholm, 2012 Available from http://www.ecdc.europa.eu/en/publications/Publications/antimicrobial-resistance-surveillance-europe-2012.pdf.

  22. Qureshi ZA, Paterson DL, Potoski BA, Kilayko MC, Sandovsky G, Sordillo E et al. Treatment outcome of bacteremia due to KPC-producing Klebsiella pneumoniae: superiority of combination antimicrobial regimens. Antimicrob Agents Chemother 2012; 56: 2108–2113.

    Article  CAS  Google Scholar 

  23. Averbuch D, Cordonnier C, Livermore DM, Mikulska M, Orasch C, Viscoli C et al. Targeted therapy against multi-resistant bacteria in leukemic and hematopoietic stem cell transplant recipients: guidelines of the 4th European Conference on Infections in Leukemia (ECIL-4, 2011). Haematologica 2013; 98: 1836–1847.

    Article  Google Scholar 

  24. Crunkhorn S . Antibacterial drugs: new antibiotics on the horizon? Nat Rev Drug Discov 2013; 12: 99.

    Article  CAS  Google Scholar 

  25. Giani T, Tascini C, Arena F, Ciullo I, Conte V, Leonildi A et al. Rapid detection of intestinal carriage of Klebsiella pneumonia producing KPC carbapenemase during an outbreak. J Hosp Infect 2012; 81: 119–122.

    Article  CAS  Google Scholar 

  26. Schwaber MJ, Lev B, Israeli A, Solter E, Smollan G, Rubinovitch B et al. Containment of a country-wide outbreak of carbapenem-resistant Klebsiella pneumoniae in Israeli hospitals via a nationally implemented intervention. Clin Infect Dis 2011; 52: 848–855.

    Article  Google Scholar 

  27. Landman D, Babu E, Shah N, Kelly P, Olawole O, Backer M et al. Transmission of carbapenem-resistant pathogens in New York City hospitals: progress and frustration. J Antimicrob Chemother 2012; 67: 1427–1431.

    Article  CAS  Google Scholar 

  28. Tascini C, Sbrana F, Flammini S, Tagliaferri E, Arena F, Leonildi A et al. Oral gentamicin gut decontamination for prevention of KPC-producing Klebsiella pneumoniae infections: the relevance of concomitant systemic antibiotic therapy. Antimicrob Agents Chemother 2014; 58: 1972–1976.

    Article  Google Scholar 

Download references

Author information

Author notes

  1. Marco Frigeni, Alessandro Rambaldi, Consuelo Corti, Fabio Ciceri, Gabriella Mometto, Claudio Annaloro, Erminia Casari, Luca Castagna, Giuseppe Rossi, Chiara Cattaneo, Domenico Russo, Valeria Cancelli, Emilio Paolo Alessandrino, Francesco Ripamonti, Fabio Pavan, Attilio Rovelli, Clara Pecoraro, Alessandro Busca, Francesca Carraro, Franca Fagioli, Susanna Gallo, Daniele Caravelli, Marco De Gobbi, Giuseppe Saglio, Claudia Castellino, Nicola Mordini, Gianluca Gaidano, Luca Nassi, Roberto Raimondi, Michele Vespignani, Anna Maria Scattolin, Irene Sara Panizzolo, Simone Cesaro, Anna Candoni, Francesca Patriarca, Andrea Bacigalupo, Annamaria Raiola, Elio Castagnola, Edoardo Lanino, Marta Stanzani, Giuseppe Bandini, Erika Massaccesi, Arcangelo Prete, Simona Bassi, Daniele Vallisa, Cecilia Caramatti, Franco Aversa, Eliana Zuffa, Stefano Guidi, Alberto Bosi, Veronica Tintori, Anna Paola Iori, Saveria Capria, Laura Cudillo, William Arcese, Teresa Dentamaro, Paolo De Fabritiis, Barbara Anaclerico, Anna Chierichini, Monica Piedimonte, Antonella Ferrari, Francesco Marchesi, Andrea Mengarelli, Elisabetta Cerchiara, Maria Cristina Tirindelli, Javid Gaziev, Alessandro Severino, Ignazio Majolino, Patrizia Chiusolo, Simona Sica, Alice Bertaina, Barbarella Lucarelli, Maria Speranza Massei, Alessandra Carotti, Katia Perruccio, Maurizio Caniglia, Stella Santarone, Paolo Di Bartolomeo, Serena Mazzotta, Piero Galieni, Attilio Olivieri, Gennaro De Rosa, Antonio Risitano, Mario Delia, Giorgina Specchia, Giulia Palazzo, Giovanni Pisapia, Giuseppe Messina, Giuseppe Irrera, Emanuele Angelucci, Donatella Baronciani, Adriana Vacca, Alessandra Crescimanno, Maurizio Musso, Rosanna Scimè, Alida Imbriani and Giuseppe Milone: Participants of the GITMO survey are listed before references.

Authors and Affiliations

  1. Dipartimento di Ematologia, Oncologia, Anatomia Patologica e Medicina Rigenerativa, Azienda Policlinico Umberto I, Sapienza University of Rome, Rome, Italy

    C Girmenia

  2. Dipartimento di Biotecnologie Mediche, University of Siena, Siena, Italy

    G M Rossolini

  3. Dipartimento di Medicina Sperimentale e Clinica, University of Florence, Florence, Italy

    G M Rossolini

  4. SOD Microbiologia e Virologia, Azienda Ospedaliera Universitaria Careggi, Florence, Italy

    G M Rossolini

  5. Fondazione GIMEMA (Gruppo Italiano Malattie EMatologiche dell’Adulto) Data Center, Rome, Italy

    A Piciocchi

  6. Unità Operativa di Oncoematologia, Ospedale pediatrico Bambino Gesù, Rome, Italy

    A Bertaina

  7. Divisione di Ematologia con Unità di Trapianto di Midollo- Ospedale S.G. Moscati, Taranto, Italy

    G Pisapia

  8. Dipartimento di Emergenza e Trapianto d’Organo, UO di Ematologia con Trapianto, University of Bari, Bari, Italy

    D Pastore

  9. Divisione di Ematologia-Istituto di Ematologia, Policlinico A. Gemelli, Università Cattolica S. Cuore, Rome, Italy

    S Sica

  10. UOC di Ematologia e Trapianti di Cellule Staminali, Az. Osp. S.Camillo-Forlanini, Rome, Italy

    A Severino

  11. Fondazione Policlinico Tor Vergata, Unità di Trapianto Cellule Staminali, University Tor Vergata, Rome, Italy

    L Cudillo

  12. Unità operative di Ematologia e trapianto Midollo Osseo, Ospedale San Raffaele, Milan, Italy

    F Ciceri

  13. UOC di Ematologia, A.O. Ospedali Riuniti Villa Sofia-Cervello, Palermo, Italy

    R Scimè

  14. Centro Nazionale Trapianti, Istituto Superiore di Sanità, Rome, Italy

    L Lombardini

  15. Dipartimento di Malattie Infettive, IRCCS S. Martino University Hospital–IST, Genoa, Italy

    C Viscoli

  16. Divisione di Ematologia, Azienda Ospedaliera Papa Giovanni XXIII, Bergamo, Italy

    A Rambaldi

Authors
  1. C Girmenia
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. G M Rossolini
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. A Piciocchi
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. A Bertaina
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. G Pisapia
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. D Pastore
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. S Sica
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. A Severino
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. L Cudillo
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. F Ciceri
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. R Scimè
    View author publications

    You can also search for this author in PubMed Google Scholar

  12. L Lombardini
    View author publications

    You can also search for this author in PubMed Google Scholar

  13. C Viscoli
    View author publications

    You can also search for this author in PubMed Google Scholar

  14. A Rambaldi
    View author publications

    You can also search for this author in PubMed Google Scholar

Consortia

the Gruppo Italiano Trapianto Midollo Osseo (GITMO)

  • Marco Frigeni
  • , Alessandro Rambaldi
  • , Consuelo Corti
  • , Fabio Ciceri
  • , Gabriella Mometto
  • , Claudio Annaloro
  • , Erminia Casari
  • , Luca Castagna
  • , Giuseppe Rossi
  • , Chiara Cattaneo
  • , Domenico Russo
  • , Valeria Cancelli
  • , Emilio Paolo Alessandrino
  • , Francesco Ripamonti
  • , Fabio Pavan
  • , Attilio Rovelli
  • , Clara Pecoraro
  • , Alessandro Busca
  • , Francesca Carraro
  • , Franca Fagioli
  • , Susanna Gallo
  • , Daniele Caravelli
  • , Marco De Gobbi
  • , Giuseppe Saglio
  • , Claudia Castellino
  • , Nicola Mordini
  • , Gianluca Gaidano
  • , Luca Nassi
  • , Roberto Raimondi
  • , Michele Vespignani
  • , Anna Maria Scattolin
  • , Irene Sara Panizzolo
  • , Simone Cesaro
  • , Anna Candoni
  • , Francesca Patriarca
  • , Andrea Bacigalupo
  • , Annamaria Raiola
  • , Elio Castagnola
  • , Edoardo Lanino
  • , Marta Stanzani
  • , Giuseppe Bandini
  • , Erika Massaccesi
  • , Arcangelo Prete
  • , Simona Bassi
  • , Daniele Vallisa
  • , Cecilia Caramatti
  • , Franco Aversa
  • , Eliana Zuffa
  • , Stefano Guidi
  • , Alberto Bosi
  • , Veronica Tintori
  • , Anna Paola Iori
  • , Saveria Capria
  • , Laura Cudillo
  • , William Arcese
  • , Teresa Dentamaro
  • , Paolo De Fabritiis
  • , Barbara Anaclerico
  • , Anna Chierichini
  • , Monica Piedimonte
  • , Antonella Ferrari
  • , Francesco Marchesi
  • , Andrea Mengarelli
  • , Elisabetta Cerchiara
  • , Maria Cristina Tirindelli
  • , Javid Gaziev
  • , Alessandro Severino
  • , Ignazio Majolino
  • , Patrizia Chiusolo
  • , Simona Sica
  • , Alice Bertaina
  • , Barbarella Lucarelli
  • , Maria Speranza Massei
  • , Alessandra Carotti
  • , Katia Perruccio
  • , Maurizio Caniglia
  • , Stella Santarone
  • , Paolo Di Bartolomeo
  • , Serena Mazzotta
  • , Piero Galieni
  • , Attilio Olivieri
  • , Gennaro De Rosa
  • , Antonio Risitano
  • , Mario Delia
  • , Giorgina Specchia
  • , Giulia Palazzo
  • , Giovanni Pisapia
  • , Giuseppe Messina
  • , Giuseppe Irrera
  • , Emanuele Angelucci
  • , Donatella Baronciani
  • , Adriana Vacca
  • , Alessandra Crescimanno
  • , Maurizio Musso
  • , Rosanna Scimè
  • , Alida Imbriani
  •  & Giuseppe Milone

Corresponding author

Correspondence to C Girmenia.

Ethics declarations

Competing interests

The authors declare no conflict of interest.

Additional information

Participants of the GITMO survey Divisione di Ematologia, Azienda Ospedaliera Papa Giovanni XXIII, Bergamo (Marco Frigeni, Alessandro Rambaldi). Unità operative di Ematologia e Trapianto Midollo Osseo, Ospedale San Raffaele, Milan (Consuelo Corti, Fabio Ciceri). Centro Trapianti di Midollo, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Milano (Gabriella Mometto, Claudio Annaloro). Humanitas Cancer Center, Humanitas Research, Rozzano, Milan (Erminia Casari, Luca Castagna). Unità Operativa di Ematologia, Azienda Spedali Civili, Brescia (Giuseppe Rossi, Chiara Cattaneo). Unità Trapianti di Midollo Osseo per Adulti, Azienda Spedali Civili, Brescia (Domenico Russo, Valeria Cancelli). Dipartimento di Ematologia Oncologica, Fondazione Istituto di Ricovero e Cure a Carattere Scientifico Policlinico San Matteo, University of Pavia, Pavia (Emilio Paolo Alessandrino, Francesco Ripamonti). UO Centro Trapianto Midollo Osseo–Fondazione MBBM, Clinica Pediatrica dell’Università di Milano-Bicocca, c/o Ospedale San Gerardo, Monza (Fabio Pavan, Attilio Rovelli). Dipartimento di Oncologia ed Ematologia A.O. Citta' della Salute e della Scienza di Torino, P.O. Molinette, Turin (Clara Pecoraro, Alessandro Busca). S.C. Oncoematologia Pediatrica e Centro Trapianti OIRM, Turin (Francesca Carraro, Franca Fagioli). Unità clinica FPO/IRCCs di Candiolo Centro Metropolitano di Torino (Susanna Gallo, Daniele Caravelli). SCDU Medicina Interna II–Ematologia, AOU San Luigi Gonzaga, Orbassano, Torino (Marco De Gobbi, Giuseppe Saglio). Divisione di Ematologia Azienda Ospedaliera S.Croce e Carle, Cuneo (Claudia Castellino, Nicola Mordini). SCDU Ematologia, AOU Maggiore della Carità, Novara (Gianluca Gaidano, Luca Nassi). Dipartimento di Ematologia, Ospedale San Bortolo, Vicenza (Roberto Raimondi). UOC Ematologia, Ospedale dell'Angelo, Mestre-Venezia (Michele Vespignani, Anna Maria Scattolin). Unità di Oncoematologia Pediatrica, Azienda Ospedaliera Universitaria Integrata, Verona (Irene Sara Panizzolo, Simone Cesaro). Clinica Ematologica e Unità di Terapie Cellulari 'Carlo Melzi'- Azienda Ospedaliera-Universitaria, Udine (Anna Candoni, Francesca Patriarca). Divisione di Ematologia II, IRCCS S. Martino University Hospital–IST, Genoa (Andrea Bacigalupo, Annamaria Raiola). Divisione Malattie Infettive e Unità di Trapianto di Midollo Osseo- Istituto Giannina Gaslini, Genoa (Elio Castagnola, Edoardo Lanino). Istituto di Ematologia e Oncologia Medica, L. e A Seragnoli, Policlinico S.Orsola Malpigli, Bologna (Marta Stanzani, Giuseppe Bandini). Programma di Oncologia, Ematologia e Trapianto di CSE, U.O. Pediatria-Prof. Pession, S. Orsola-Malpighi, University of Bologna, Bologna (Erika Massaccesi, Arcangelo Prete). Ospedale Civile di Piacenza, 1a Divisione Medica Onco-Ematologia, Piacenza (Simona Bassi, Daniele Vallisa). Ematologia e Centro Trapianti Midollo Osseo, Ospedale Maggiore, Parma (Cecilia Caramatti, Franco Aversa). UO Ematologia–Ospedale Santa Maria delle Croci, Ravenna (Eliana Zuffa). Cattedra di Ematologia, Azienda Ospedaliera di Careggi, Florence (Stefano Guidi, Alberto Bosi). Meyer Children Hospital, Florence (Veronica Tintori). Dipartimento di Ematologia, Oncologia, Anatomia Patologica e Medicina Rigenerativa, Azienda Policlinico Umberto I, Sapienza University, Rome (Anna Paola Iori, Saveria Capria). Fondazione Policlinico Tor Vergata, Unità di Trapianto Cellule Staminali, University Tor Vergata, Rome (Laura Cudillo, William Arcese). Divisione di Ematologia, Ospedale S.Eugenio, Rome (Teresa Dentamaro, Paolo De Fabritiis). Unità Operativa di Ematologia, Azienda Ospedaliera San Giovanni Addolorata, Rome (Barbara Anaclerico, Anna Chierichini). UOC Ematologia, Azienda Ospedaliera Sant'Andrea, Facoltà di Medicina e Psicologia–Sapienza University, Rome (Monica Piedimonte, Antonella Ferrari). UOC di Ematologia e Trapianti, Istituto Nazionale Tumori Regina Elena, IFO, Rome (Francesco Marchesi, Andrea Mengarelli). UOC Ematologia Trapianto Cellule Staminali, Medicina Trasfusionale e Terapia Cellulare, Università Campus Biomedico, Rome (Elisabetta Cerchiara, Maria Cristina Tirindelli). Istituto Mediterraneo di Ematologia, Policlinico Tor Vergata, Rome ( Javid Gaziev). UOC di Ematologia e Trapianti di Cellule Staminali, Az. Osp. S.Camillo-Forlanini, Rome (Alessandro Severino, Ignazio Majolino). Divisione di Ematologia- Istituto di Ematologia, Policlinico A. Gemelli, Università Cattolica S. Cuore, Rome (Patrizia Chiusolo, Simona Sica). Unità Operativa di Oncoematologia, Ospedale pediatrico Bambino Gesù, Rome (Alice Bertaina, Barbarella Lucarelli). Trapianto di Midollo Osseo Ospedale Santa Maria della Misericordia; Perugia (Maria Speranza Massei, Alessandra Carotti). S.C. Oncoematologia Pediatrica, Perugia (Katia Perruccio, Maurizio Caniglia). UOC di Trapianto Emopoietico, Ospedale Spirito Santo, Pescara (Stella Santarone, Paolo Di Bartolomeo). UOC di Ematologia, Ospedale C e G Mazzoni, Ascoli Piceno (Serena Mazzotta, Piero Galieni). Clinica di Ematologia, Azienda Ospedaliero-Universitaria Ospedali Riuniti di Ancona, Ancona, (Attilio Olivieri). Ematologia, Dipartimento di medicina e chirurgia, Universita degli studi di Napoli Federico II; Naples (Gennaro De Rosa, Antonio Risitano). Ematologia con Trapianto, Dipartimento di Emergenza e Trapianto d'Organo, University of Bari, Bari (Mario Delia, Giorgina Specchia)Divisione di Ematologia con Unità di Trapianto di Midollo- Ospedale S.G. Moscati, Taranto (Giulia Palazzo, Giovanni Pisapia). Divisione di Ematologia Centro Unico Regionale TMO e Terapie Emato-Oncologiche Sovramassimali “A. Neri” Ospedale Bianchi-Melacrino-Morelli, Reggio Calabria (Giuseppe Messina, Giuseppe Irrera). Centro Trapianti “Wilma Deplano” Ospedale oncologico Armando Businco, Cagliari (Emanuele Angelucci, Donatella Baronciani). Ematologia - Centro trapianti di midollo osseo, P.O. “R. Binaghi”, Cagliari (Adriana Vacca). U.O di Oncoematologia e TMO Dip. Oncologico La Maddalena, Palermo (Alessandra Crescimanno, Maurizio Musso). UOC di Ematologia, A.O. Ospedali Riuniti Villa Sofia-Cervello, Palermo (Rosanna Scimè). Cattedra di Ematologia - Ospedale Ferrarotto, Univ. degli Studi di Catania, Catania (Alida Imbriani, Giuseppe Milone).

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Girmenia, C., Rossolini, G., Piciocchi, A. et al. Infections by carbapenem-resistant Klebsiella pneumoniae in SCT recipients: a nationwide retrospective survey from Italy. Bone Marrow Transplant 50, 282–288 (2015). https://doi.org/10.1038/bmt.2014.231

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/bmt.2014.231

This article is cited by

Search

Advanced search

Quick links