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High incidence of CMV infection in adult T-cell leukemia/lymphoma patients after allogeneic hematopoietic stem cell transplantation

Bone Marrow Transplantation volume 49, pages 1548–1549 (2014)Cite this article

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CMV diseases are one of the significant factors contributing to morbidity and mortality in recipients of allogeneic hematopoietic stem cell transplantation (HSCT).1 Preemptive therapy for active CMV infection based on monitoring CMV pp65 antigenemia and/or CMV-DNA PCR assay has been attempted.2 In Japan, only the CMV pp65 antigenemia test is covered by the National Health Insurance program. Adult T-cell leukemia/lymphoma (ATLL), which is a human T-lymphotropic virus type I-related hematological malignancy, is known to have a poor prognosis. So far there have only been a few reports about the incidence of CMV infection in ATLL patients following allogeneic HSCT.3 Here we have analyzed the incidence of CMV infection and related clinical issues in 52 allogeneic HSCT recipients.

Eighty-five patients, who survived at least 30 days after HSCT, consecutively underwent allogeneic HSCT from November 2006 to May 2012 at Imamura Bun-in Hospital, Kagoshima, Japan. Thirty-three patients were excluded from this study for lack of necessary data. The remaining 52 (male: 34, female: 18) patients were analyzed as below (Table 1).

Table 1 Patients’ characteristics
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Acknowledgements

We thank all of our patients and nurses for their sincere efforts and cooperation for this study. We also thank Stephanie Napier for critically reading this manuscript, and Minako Nobori and Yasuko Tsuji for secretarial assistance. This work was supported in part by a Grant-in-Aid from the Japanese Ministry of Health, Labor, and Welfare (H 22-Clinical Cancer Research-Ippan-028).

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Authors and Affiliations

  1. Department of Hematology, Imamura Bun-in Hospital, Kagoshima, Japan

    N Nakano, A Kubota, M Tokunaga, M Tokunaga, T Itoyama, T Makino, S Takeuchi, Y Takatsuka & A Utsunomiya

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  1. N Nakano
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  2. A Kubota
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  3. M Tokunaga
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  8. Y Takatsuka
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  9. A Utsunomiya
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Correspondence to N Nakano.

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Nakano, N., Kubota, A., Tokunaga, M. et al. High incidence of CMV infection in adult T-cell leukemia/lymphoma patients after allogeneic hematopoietic stem cell transplantation. Bone Marrow Transplant 49, 1548–1549 (2014). https://doi.org/10.1038/bmt.2014.204

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