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  • Original Article
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Histocompatibility and Donor Selection

Donor choice according to age for allo-SCT for AML in complete remission

Bone Marrow Transplantation volume 48, pages 1028–1032 (2013)Cite this article

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Abstract

In a retrospective study of 168 patients with AML in CR who underwent allo-SCT, we compare the impact of young unrelated donors (UD) vs older matched related donors (MRD) on 5-year OS (5-yr OS). Median follow-up was 59 months and median donor age was 39 years, which was used as cutoff for young vs older donors. Kaplan–Meier-estimated 5-yr OS was better with UD ⩽39 years vs MRD >39 years (66% vs 34%, P=0.001). In multivariate analysis, only donor age and cytogenetic risk impacted 5-yr OS. Compared with UD ⩽39 years, both MRD >39 years (relative risk (RR): 4.31, P=0.001) and UD >39 years (RR: 2.14, P=0.03) were associated with poorer 5-yr OS. Standard-risk cytogenetics was associated with better 5-yr OS compared with bad-risk cytogenetics, (RR: 0.53, P=0.02). Subgroup analyses of patients ⩾50 years (n=76) revealed similar results, with 5-yr OS of 62% for UD ⩽39 yrs and 26% for MRD >39 yrs (P=0.022). In patients undergoing allo-HSCT for AML, young UD may improve outcome as compared with older MRD.

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Acknowledgements

We thank the nurses of the BMT wards for taking care of our patients, the study nurses for their assistance and the medical technicians and scientists for their work in the BMT laboratories.

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Authors and Affiliations

  1. Clinic for Stem Cell Transplantation, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

    F Ayuk, T Zabelina, F Wortmann, H Alchalby, C Wolschke, H Lellek, U Bacher, A Zander & N Kröger

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  1. F Ayuk
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  2. T Zabelina
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  3. F Wortmann
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  4. H Alchalby
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  8. A Zander
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Correspondence to F Ayuk.

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Supplementary Information accompanies the paper on Bone Marrow Transplantation website

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Ayuk, F., Zabelina, T., Wortmann, F. et al. Donor choice according to age for allo-SCT for AML in complete remission. Bone Marrow Transplant 48, 1028–1032 (2013). https://doi.org/10.1038/bmt.2013.14

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