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Allografting

Allogeneic matched-sibling hematopoietic cell transplantation for AML: comparable outcomes between Eastern Mediterranean (EMBMT) and European (EBMT) centers

Bone Marrow Transplantation volume 48, pages 1065–1069 (2013)Cite this article

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Abstract

Allogeneic hematopoietic cell transplantation (HCT) activity significantly increased in the Eastern Mediterranean area over the past decade. However, comparative outcomes with longer established centers, especially European Blood and Marrow Transplantation (EBMT) centers, have not been reported. We compared outcomes of matched-sibling allogeneic HCT between East Mediterranean Blood and Marrow Transplantation (EMBMT) and EBMT centers for adult patients with AML in first CR using myeloablative conditioning. We matched 431 patients from EMBMT with 431 patients from EBMT centers according to patient, disease and transplant characteristics. EMBMT recipients and donors were more likely to be CMV seropositive. There were no significant differences in the incidence of acute or chronic GVHD, or the 3-year cumulative incidence of non-relapse mortality (NRM) and relapse incidence (RI) between the two groups (NRM: EMBMT=16% vs EBMT=11), (RI: EMBMT=13% vs EBMT=19%). Notably, the 3-year leukemia-free survival (LFS) and OS were similar between the groups (LFS: EMBMT=70±2% vs EBMT=69±3%), (OS: EMBMT=74±2% vs EBMT=73±2%). Despite differences in socioeconomics, health resources and transplant experience, matched-sibling allogeneic HCT outcomes in emerging centers in the EMBMT region appear similar to EBMT centers.

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Authors and Affiliations

  1. Department of Internal Medicine, American University Beirut Medical Center, Beirut, Lebanon

    A Bazarbachi & M A Kharfan-Dabaja

  2. AP-HP, Hôpital Saint Antoine, service d’hématologie et thérapie cellulaire, Paris, France

    M Labopin

  3. Tehran University of Medical Sciences, Hematology, Oncology and Stem Cell Transplantation research center, Tehran, Iran

    A Ghavamzadeh, A A Hamidieh & K Alimoghaddam

  4. Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice, Poland

    S Giebel

  5. King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia

    H Al-Zahrani, W Rasheed & M Aljurf

  6. Center National de Greffe de Moelle Osseuse de Tunis, Tunis, Tunisia

    S Ladeb

  7. Department of Hematology, Università Cattolica del Sacro Cuore, Rome, Italy

    G Leone

  8. King Hussein Cancer Center, Amman, Jordan

    F Abdel-Rahman

  9. Department of Hematology, Università di Bari, Bari, Italy

    V Liso

  10. Makassed General Hospital, Beirut, Lebanon

    A Ibrahim

  11. Riyadh Military Hospital, Riyadh, Saudi Arabia

    A Alabdulaaly

  12. Department of Hematology and Bone Marrow Transplantation, Silesian Medical University, Katowice, Poland

    S Kyrcz-Krzemien

  13. Department of Hematology, Charité-Universitätsmedizin Berlin, Berlin, Germany

    R Arnold

  14. Department of Hematology, Université de Nantes, Nantes, France

    M Mohty

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  1. A Bazarbachi
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  2. M Labopin
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  10. A A Hamidieh
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  14. S Kyrcz-Krzemien
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  15. R Arnold
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  16. M A Kharfan-Dabaja
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  17. K Alimoghaddam
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Correspondence to A Bazarbachi.

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Bazarbachi, A., Labopin, M., Ghavamzadeh, A. et al. Allogeneic matched-sibling hematopoietic cell transplantation for AML: comparable outcomes between Eastern Mediterranean (EMBMT) and European (EBMT) centers. Bone Marrow Transplant 48, 1065–1069 (2013). https://doi.org/10.1038/bmt.2013.1

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