Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Original Article
  • Published:

Quality of Life

Comparison of early quality of life outcomes in autologous and allogeneic transplant patients

Bone Marrow Transplantation volume 47, pages 1577–1582 (2012)Cite this article

Subjects

Abstract

The Functional Assessment of Cancer Therapy-Bone Marrow Transplant measures quality of life (QOL) in SCT patients. Prior reports found mixed results regarding QOL differences among autologous and allogeneic SCT patients. In addition, there is a paucity of literature examining differences in QOL patterns over time between autologous and allogeneic patients. The present study examines differences in QOL between patients free of clinical depression undergoing autologous (n=41) and allogeneic (n=64) SCT during early stages of treatment. Despite clinical differences, autologous and allogeneic patients demonstrated similar changes in QOL. The exception was the Functional subscale which indicated worse QOL for allogeneic patients at discharge (F test=4.61, df=1, P<0.05); allogeneic patients (Mean=13.06, s.d.=5.36) indicated they were less able to function at work and were less accepting of their illness than autologous patients (Mean=16.02, s.d.=6.73). There was a significant main effect for time on nearly all QOL subscales (P<0.05) demonstrating decline during treatment and return to baseline by discharge; only the Social Well-Being scale did not significantly change over time. These results help to understand patients’ response to SCT in the earliest stages and ultimately help identify patients at risk who could benefit from therapeutic interventions.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1

Similar content being viewed by others

References

  1. Andrykowski M . Psychosocial factors in bone marrow transplantation: A review and recommendations for research. Bone Marrow Transplant 1994; 13: 357–375.

    CAS  PubMed  Google Scholar 

  2. McQuellon RP, Russell GB, Cella DF, Craven BL, Brady M, Bonomi A et al. Quality of life measurement in bone marrow transplantation: development of the Functional Assessment of Cancer Therapy-Bone Marrow Transplant (FACT-BMT) scale. Bone Marrow Transplant 1997; 19: 357–368.

    Article  CAS  PubMed  Google Scholar 

  3. Byar K, Eilers J, Nuss S . Quality of life five or more years post-autologous hematopoietic stem cell transplant. Cancer Nurs 2005; 28: 148–157.

    Article  PubMed  Google Scholar 

  4. Heinonen H, Volin L, Uutela A, Zevon M, Barrick C, Ruutu T . Quality of life and factors related to perceived satisfaction with quality of life after allogeneic bone marrow transplantation. Ann Hematol 2001; 80: 137–143.

    Article  CAS  PubMed  Google Scholar 

  5. Stewart S . Autologous Stem Cell Transplant. A handbook for patients. Highland Park, IL: BMT InfoNet, 2006.

    Google Scholar 

  6. Pasquini M, Wang Z, Schneider L . Current use and outcome of hematopoietic stem cell transplantation: part I-CIBMTR summary slides. CIBMT Newslett 2007; 13: 5–9.

    Google Scholar 

  7. Van Besien K, Loberiza FR, Bajorunaite R, Armitage JO, Bashey A, Burns LJ et al. Comparison of autologous and allogeneic hematopoietic stem cell transplantation for follicular lymphoma. Blood 2003; 102: 3521–3529.

    Article  CAS  PubMed  Google Scholar 

  8. Zittoun R, Suciu S, Watson M, Solbu G, Muus P, Mandelli F et al. Quality of life in patients with acute myelogenous leukemia in prolonged first complete remission after bone marrow transplantation (allogeneic or autologous) or chemotherapy: a cross-sectional study of the EORTC-GINEMA AML 8A trial. Bone Marrow Transplant 1997; 20: 307–315.

    Article  CAS  PubMed  Google Scholar 

  9. Hjermstad MJ, Holte H, Evensen SA, Fayers PM, Kaasa S . Do patients who are treated with stem cell transplantation have a health-related quality of life comparable to the general population after 1 year. Bone Marrow Transplant 1999; 24: 911–918.

    Article  CAS  PubMed  Google Scholar 

  10. Andorsky DJ, Loberiza FR, Lee SJ . Pre-transplantation physical and mental functioning is strongly associated with self-reported recovery from stem cell transplantation. Bone Marrow Transplant 2006; 37: 889–895.

    Article  CAS  PubMed  Google Scholar 

  11. Leigh S, Wilson K, Burns R, Clark R . Psychosocial morbidity in bone marrow transplant recipients: a prospective study. Bone Marrow Transplant 1995; 16: 635–640.

    CAS  PubMed  Google Scholar 

  12. Syrjala KL, Chapko MK, Vitaliano PP, Cummings C, Sullivan KM . Recovering after allogeneic marrow transplantation: prospective study of predictors of long-term physical and psychosocial functioning. Bone Marrow Transplant 1993; 11: 319–327.

    CAS  PubMed  Google Scholar 

  13. Stiff P, Miller L, Mumby P, Kiley K, Batiste R, Porter N et al. Patients’ understanding of disease status and treatment plan at initial hematopoietic stem cell transplantation consultation. Bone Marrow Transplant 2006; 37: 479–489.

    Article  CAS  PubMed  Google Scholar 

  14. Trask PC, Paterson A, Riba A, Brines B, Griffith K, Parker P et al. Assessment of psychological distress in prospective bone marrow transplant patients. Bone Marrow Transplant 2002; 29: 917–925.

    Article  CAS  PubMed  Google Scholar 

  15. Gaston-Johansson F, Foxall M . Psychological correlates of quality of life across the autologous bone marrow transplant experience. Cancer Nurs 1996; 19: 170–176.

    Article  CAS  PubMed  Google Scholar 

  16. Andrykowski M, Bishop M, Hahn E, Cella D, Beaumont J, Brady M et al. Long-term health-related quality of life, growth, and spiritual well-being after hematopoietic stem-cell transplantation. J Clin Oncol 2005; 23: 599–608.

    Article  PubMed  Google Scholar 

  17. Worel N, Biener D, Kalhs P, Mitterbauer M, Keil F, Schulenburg A et al. Long-term outcome and quality of life of patient who are alive and in complete remission more than two years after allogeneic and syngeneic stem cell transplantation. Bone Marrow Transplant 2002; 30: 619–626.

    Article  CAS  PubMed  Google Scholar 

  18. Grulke N, Bailer H, Kachele H, Bunjes D . Psychological distress of patients undergoing intensified conditioning with radioimmunotherapy prior to allogeneic stem cell transplantation. Bone Marrow Transplant 2005; 35: 1107–1111.

    Article  CAS  PubMed  Google Scholar 

  19. Syrjala K, Langer S, Abrams J, Storer B, Sanders J, Flowers M et al. Recovery and long-term function after hematopoietic cell transplantation for leukemia or lymphoma. JAMA 2004; 291: 2335–2343.

    Article  CAS  PubMed  Google Scholar 

  20. Mumby P, Garcia C, Trivedi-Purohit R, Gourvitz R, Rychlik K, Rodriguez T et al. The impact of pharmacotherapy on depression and quality of life in patients undergoing a bone marrow transplant. J Clin Oncol 2010; 28(15S): 668s.

    Google Scholar 

  21. Beck A, Steer R, Brown G . Beck Depression Inventory: Manual. 2d ed. Harcourt Brace: Boston, 1996.

    Google Scholar 

  22. Cella D, Tulsky D, Gray G, Sarafian B, Linn E, Bonomi A et al. The functional assessment of cancer therapy scale: development and validation of the general measure. J Clin Oncol 1993; 11: 570–579.

    Article  CAS  PubMed  Google Scholar 

  23. Brady M, Cella D, Mo F, Bonomi A, Tulsky D, Lloyd S et al. Reliability and validity of the functional assessment of cancer therapy-breast (FACT-B) quality of life instrument. J Clin Oncol 1997; 15: 974–986.

    Article  CAS  PubMed  Google Scholar 

  24. Cella D, Bonomi A, Lloyd S, Tulsky D, Kaplan E, Bonomi P . Reliability and validity of the functional assessment of cancer therapy-lung (FACT-L) quality of life instrument. Lung Cancer 1995; 12: 199–220.

    Article  CAS  PubMed  Google Scholar 

  25. Weitzner M, Meyers C, Gelke C, Byrne K, Cella D, Levin V . The functional assessment of cancer therapy (FACT) scale: Development of a brain subscale and revalidation of the general version (FACT-G) in patients with primary brain tumors. Cancer 1995; 75: 1151–1161.

    Article  CAS  PubMed  Google Scholar 

  26. Faul F, Erdfelder E, Lang AG, Buchner A . G*Power 3: A flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Behav Res Methods 2007; 39: 175–191.

    Article  PubMed  Google Scholar 

  27. Mosher CE, Redd WH, Rini CM, Burkhalter JE, DuHamel KN . Physical, psychological, and social sequelae following hematopoietic stem cell transplantation: a review of the literature. Psychooncology 2009; 18: 113–127.

    Article  PubMed  PubMed Central  Google Scholar 

  28. Rini C, Redd W, Austin J, Mosher C, Meschian Y, Isola L et al. Effectiveness of partner social support predicts enduring psychological distress after haematopoietic stem cell transplantation. J Consult Clin Psychol 2011; 79: 64–74.

    Article  PubMed  PubMed Central  Google Scholar 

  29. Beeken R, Eiser C, Dalley C . Health-related quality of life in haematopoietic stem cell transplant survivors: a qualitative study on the role of psychosocial variables and response shifts. Qual Life Res 2010; 20: 153–160.

    Article  PubMed  Google Scholar 

  30. Rankin NM, Butow PN, Price MA, Evans A . Views of psycho-oncology health professionals on priority psycho-oncology research questions. Support Care Cancer 2011; 19: 1133–1141.

    Article  PubMed  Google Scholar 

  31. Jacobsen PB, Ransom S . Implementation of NCCN distress management guidelines by member institutions. J Natl Compr Canc Netw 2007; 5: 99–103.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. College of Psychology, Illinois Institute of Technology, Chicago, IL, USA

    C M Garcia

  2. Department of Psychiatry and Behavioral Neurosciences, Loyola University Medical Center, Chicago, IL, USA

    P B Mumby & S Thilges

  3. Department of Medicine, Loyola University Medical Center, Chicago, IL, USA

    P J Stiff

Authors
  1. C M Garcia
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. P B Mumby
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. S Thilges
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. P J Stiff
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to P B Mumby.

Ethics declarations

Competing interests

The authors declare no conflict of interest.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Garcia, C., Mumby, P., Thilges, S. et al. Comparison of early quality of life outcomes in autologous and allogeneic transplant patients. Bone Marrow Transplant 47, 1577–1582 (2012). https://doi.org/10.1038/bmt.2012.77

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/bmt.2012.77

Keywords

This article is cited by

Search

Advanced search

Quick links