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Cord blood transplantation in aplastic anemia

Abstract

For patients with inherited BM failure (BMF) or those with acquired BMF who fail immunosuppressive therapy and who lack a suitable alternative donor, the prognosis remains poor. Umbilical cord blood transplantation has extended the availability of hematopoietic stem cell transplantation in the absence of a suitable donor. A recent EBMT study confirmed the feasibility of this treatment and highlighted the fundamental role of the TNC dose (>3.9 × 107/kg TNC/kg) on both engraftment and OS using cord blood as stem cell source in severe aplastic anemia. However, this procedure is still experimental and should be evaluated only through prospective clinical trials.

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Correspondence to R Peffault de Latour.

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Peffault de Latour, R., Rocha, V. & Socié, G. Cord blood transplantation in aplastic anemia. Bone Marrow Transplant 48, 201–202 (2013). https://doi.org/10.1038/bmt.2012.252

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