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Post-Transplant Events

Risk factors affecting cardiac left-ventricular hypertrophy and systolic and diastolic function in the chronic phase of allogeneic hematopoietic cell transplantation

Bone Marrow Transplantation volume 48, pages 581–586 (2013)Cite this article

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Abstract

Chronic impairment of cardiac function can be an important health risk and impair the quality of life, and may even be life-threatening for long-term survivors of allogeneic hematopoietic cell transplantation (HCT). However, risk factors for and/or the underlying mechanism of cardiac dysfunction in the chronic phase of HCT are still not fully understood. We retrospectively investigated factors affecting cardiac function and left-ventricular hypertrophy (LVH) in the chronic phase of HCT. Sixty-three recipients who survived for >1 year after receiving HCT were evaluated using echocardiography. Based on simple linear regression models, high-dose TBI-based conditioning was significantly associated with a decrease in left-ventricular ejection fraction and the early peak flow velocity/atrial peak flow velocity ratio, following HCT (coefficient=−5.550, P=0.02 and coefficient=−0.268, P=0.02, respectively). These associations remained significant with the use of multiple linear regression models. Additionally, the serum ferritin (s-ferritin) level before HCT was found to be a significant risk factor for LVH on multivariable logistic analysis (P=0.03). In conclusion, our study demonstrated that a myeloablative regimen, especially one that involved high-dose TBI, impaired cardiac function, and that a high s-ferritin level might be associated with the development of LVH in the chronic phase of HCT.

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Acknowledgements

This work was supported by a Grant-in-Aid for Scientific Research from the Japanese Ministry of Education, Science, Sports, and Culture, and a grant from the Japanese Ministry of Health, Welfare, and Labour.

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Authors and Affiliations

  1. Hematology, Graduate School of Medicine, Osaka City University, Osaka, Japan

    M Nishimoto, H Nakamae, H Koh, T Nakane, M Nakamae, A Hirose, K Hagihara, Y Nakao, Y Terada & M Hino

  2. Department of Diagnostic Pathology, Graduate School of Medicine, Osaka City University, Osaka, Japan

    M Ohsawa

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  1. M Nishimoto
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  2. H Nakamae
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Correspondence to H Nakamae.

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Nishimoto, M., Nakamae, H., Koh, H. et al. Risk factors affecting cardiac left-ventricular hypertrophy and systolic and diastolic function in the chronic phase of allogeneic hematopoietic cell transplantation. Bone Marrow Transplant 48, 581–586 (2013). https://doi.org/10.1038/bmt.2012.179

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