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Long-term outcomes after hematopoietic SCT for adult T-cell leukemia/lymphoma: results of prospective trials

Bone Marrow Transplantation volume 46, pages 116–118 (2011)Cite this article

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Abstract

We have previously conducted clinical trials of allogeneic hematopoietic SCT with reduced-intensity conditioning regimen (RIC) for adult T-cell leukemia/lymphoma (ATLL)—a disease caused by human T-lymphotropic virus type 1 (HTLV-1) infection and having a dismal prognosis. Long-term follow-up studies of these trials revealed that 10 of the 29 patients have survived for a median of 82 months (range, 54–100 months) after RIC, indicating a possible curability of the disease by RIC. However, we have also observed that the patterns of post-RIC changes in HTLV-1 proviral load over time among the 10 survivors were classified into three patterns. This is the first report to clarify the long-term outcomes after RIC for ATLL patients.

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Authors and Affiliations

  1. Department of Hematology, National Kyushu Cancer Center, Fukuoka, Japan

    I Choi & N Uike

  2. Stem Cell Transplantation Unit, National Cancer Center Hospital, Tokyo, Japan

    R Tanosaki

  3. Department of Hematology, Imamura Bun-in Hospital, Kagoshima, Japan

    A Utsunomiya

  4. Department of Hematology, Molecular Medicine Unit, Atomic Bomb Disease Institute, School of Medicine, Nagasaki University, Nagasaki, Japan

    M Tomonaga

  5. Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan

    M Harada

  6. National Kyushu Cancer Center, Institute for Clinical Research, Fukuoka, Japan

    T Yamanaka & J Okamura

  7. Medical Research Division, Department of Immunotherapeutics, Tokyo Medical and Dental University, Tokyo, Japan

    M Kannagi

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  1. I Choi
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  2. R Tanosaki
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  3. N Uike
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  4. A Utsunomiya
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  5. M Tomonaga
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  6. M Harada
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  7. T Yamanaka
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  8. M Kannagi
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  9. J Okamura
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on behalf of the ATLL allo-HSCT Study Group

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Correspondence to J Okamura.

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Choi, I., Tanosaki, R., Uike, N. et al. Long-term outcomes after hematopoietic SCT for adult T-cell leukemia/lymphoma: results of prospective trials. Bone Marrow Transplant 46, 116–118 (2011). https://doi.org/10.1038/bmt.2010.92

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  • DOI: https://doi.org/10.1038/bmt.2010.92

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