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Stable low-level donor-cell engraftment in a patient with X-linked lymphoproliferative disease following matched unrelated allo-SCT

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References

  1. Purtilo DT, Cassel CK, Yang JP, Harper R . X-linked recessive progressive combined variable immunodeficiency (Duncan's disease). Lancet 1975; 1: 935–940.

    Article  CAS  PubMed  Google Scholar 

  2. Coffey AJ, Brooksbank RA, Brandau O, Oohashi T, Howell GR, Bye JM et al. Host response to EBV infection in X-linked lymphoproliferative disease results from mutations in an SH2-domain encoding gene. Nat Genet 1998; 20: 129–135.

    Article  CAS  PubMed  Google Scholar 

  3. Seemayer TA, Gross TG, Egeler RM, Pirruccello SJ, Davis JR, Kelly CM et al. X-linked lymphoproliferative disease: twenty-five years after the discovery. Pediatr Res 1995; 38: 471–478.

    Article  CAS  PubMed  Google Scholar 

  4. Bond J, Shahdapuri R, McMahon C, O'Marcaigh A, Cotter M, Smith O . Successful treatment of acute Epstein-Barr virus infection associated with X-linked lymphoproliferative disorder with rituximab. Paediatr Blood Cancer 2007; 49: 761–762.

    Article  Google Scholar 

  5. Lee TL, Law HKW, Chan GCF, Ha SY, Ho MHK, Chan KW et al. Successful treatment of X-linked lymphoproliferative disease (XLP) with anti-CD20 monoclonal antibody (rituximab) followed by mismatched unrelated cord blood transplantation. HK J Paediatr 2006; 11: 210–214.

    Google Scholar 

  6. Hoffman T, Heilman C, Madsen HO, Vindelov L, Schmeigelow K . Matched unrelated allogeneic bone marrow transplantation for recurrent malignant lymphoma in a patient with X-linked lymphoproliferative disease (XLP). Bone Marrow Transplant 1998; 22: 603–604.

    Article  Google Scholar 

  7. Lankester AC, Visser LF, Hartwig NG, Bredius RGM, Gaspar HB, van der Burg M et al. Allogeneic stem cell transplantation in X-linked lymphoproliferative disease: two cases in one family and review of the literature. Bone Marrow Transplant 2005; 36: 99–105.

    Article  CAS  PubMed  Google Scholar 

  8. Ozyurek E, Cowan MJ, Koerper MA, Baxter-Lowe LA, Dvorak CC, Horn BN . Increasing mixed chimerism and the risk of graft loss in children undergoing allogeneic hematopoietic stem cell transplantation for non-malignant disorders. Bone Marrow Transplant 2008; 42: 83–91.

    Article  CAS  PubMed  Google Scholar 

  9. Cohen JM, Sebire NJ, Harvey J, Gapsar HB, Cathy C, Jones A et al. Successful treatment of lymphoproliferative disease complicating primary immunodeficiency/immunodysregulatory disorders with reduced-intensity allogeneic stem-cell transplantation. Blood 2007; 110: 2209–2214.

    Article  CAS  PubMed  Google Scholar 

  10. Cooper N, Rao K, Gilmour K, Hadad L, Adams S, Cale C et al. Stem cell transplantation with reduced-intensity conditioning for hemophagocytic lymphohistiocytosis. Blood 2006; 107: 1233–1236.

    Article  CAS  PubMed  Google Scholar 

  11. Slatter MA, Bhattacharya A, Abinun M, Flood TJ, Cant AJ, Gennery AR . Outcome of boost haemopoietic stem cell transplant for decreased donor chimerism or graft dysfunction in primary immunodeficiency. Bone Marrow Transplant 2005; 35: 683–689.

    Article  CAS  PubMed  Google Scholar 

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Haslam, K., Molloy, K., Langabeer, S. et al. Stable low-level donor-cell engraftment in a patient with X-linked lymphoproliferative disease following matched unrelated allo-SCT. Bone Marrow Transplant 46, 1263–1264 (2011). https://doi.org/10.1038/bmt.2010.266

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