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Early immune reconstitution and efficient graft vs tumor effect after unrelated partially matched double cord blood transplantation in refractory 8p11 syndrome

Bone Marrow Transplantation volume 46, pages 622–624 (2011)Cite this article

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The 8p11 myeloproliferative syndrome is a rare hematological malignancy characterized by a CML-like hyperplasia in blood and marrow and a non-Hodgkin's lymphoma involvement in lymph nodes, which are mostly of a T-lymphoblastic subtype. The median survival is <12 months and depends on chemosensitivity and the opportunity to perform rapidly allogeneic hematopoietic cell transplantation.1

The patient received induction chemotherapy consisting of four ACBVP courses (prednisolone 60 mg/m2 from day 1 to day 5, vindesine 2 mg/m2 at days 1 and 5, doxorubicin 75 mg/m2 at day 1, bleomycin 10 mg total dose at days 1 and 5, CY 1200 mg/m2 at day 1) and after 3 months a PR was achieved. In the absence of a matched sibling donor, an allogeneic PBSC transplant was planned but the sole eligible donor was revealed to show active tuberculosis 10 days before stem cell collection. The patient's condition progressed and he was administered second-line platinum-based chemotherapy and obtained a second PR.

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Acknowledgements

We thank Frances Sheppard, Clinical Investigation Centre, Besancon for proofreading the article.

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Authors and Affiliations

  1. CHU Besançon, Service d’Hématologie— Secteur greffe, Besançon, France

    F Larosa, F Legrand & E Deconinck

  2. Etablissement Français du sang Bourgogne Franche-Comté, Activité d’Ingénierie et de Thérapie Cellulaire, Besançon cedex, France

    S Maddens & F Pouthier

  3. Inserm UMR645, Besançon cedex, France

    C Ferrand, P Saas, P Tiberghien, P S Rohrlich & E Deconinck

  4. Université de Franche-Comté, Besançon, France

    C Ferrand, P Saas, P Tiberghien, P S Rohrlich & E Deconinck

  5. EFS Bourgogne Franche-Comté, Plateforme de Biomonitoring, CIC-BT506, Besançon cedex, France

    C Ferrand, P Saas & P Tiberghien

  6. Centre d’Investigation Clinique en Biothérapies 506, Hôpital Saint Jacques, CHU de Besançon, France

    P Saas

  7. CHU Lyon, Laboratoire de Biologie Moléculaire, Pierre Bénite, Lyon, France

    S Hayette

  8. EFS Bourgogne Franche-Comté, Laboratoire HLA, Besançon cedex, France

    J Chabod & P Tiberghien

  9. CHU Besançon Service d’Hématologie Pédiatrie, Besançon, France

    P S Rohrlich

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  1. F Larosa
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  11. E Deconinck
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Corresponding authors

Correspondence to F Larosa or E Deconinck.

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The authors declare no conflict of interest.

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Larosa, F., Maddens, S., Legrand, F. et al. Early immune reconstitution and efficient graft vs tumor effect after unrelated partially matched double cord blood transplantation in refractory 8p11 syndrome. Bone Marrow Transplant 46, 622–624 (2011). https://doi.org/10.1038/bmt.2010.171

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