Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Original Article
  • Published:

Post-Transplant Events

High incidence of oral squamous cell carcinoma independent of HPV infection after allogeneic hematopoietic SCT in Taiwan

Abstract

Hematopoietic SCT (HSCT) is a well-recognized therapeutic procedure to prolong life and cure patients with life-threatening hematological malignancies; however, the risk of developing secondary carcinoma may increase in long-term survivors. The objective of this study was to determine the incidence and risk factors for secondary squamous carcinoma after HSCT. Between 1984 and 2004, 170 allogeneic HSCT recipients aged >15 years, who had survived for >5 years were enrolled. Demographic data and the characteristics of secondary carcinoma were collected and analyzed for the determination of the incidence and risk of developing secondary carcinoma. Eight patients developed secondary carcinoma, including five oral squamous cell carcinomas, one esophageal, one gastric and one ovarian carcinoma, but no cutaneous carcinomas were detected at a median follow-up of 14.1 years (range, 5.1–23.3 years) after HSCT. The accrual 10-year cumulative incidence of secondary carcinoma was 2.89%. In univariate and multivariate analyses, chronic GVHD and age >40 years at the time of HSCT were both significant risk factors independently associated with the development of secondary carcinoma. Thus, the occurrence of secondary carcinoma is one of the late complications in patients undergoing HSCT. Oral squamous cell carcinoma was more common in our patients after HSCT, indicating the need for lifelong surveillance of the oral cavity. Moreover, because of the relatively long latency in developing secondary carcinoma, extended follow-up is required for a thorough understanding of the incidence and characteristics of secondary carcinoma after HSCT.

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Prices may be subject to local taxes which are calculated during checkout

Figure 1
Figure 2

Similar content being viewed by others

References

  1. Marras TK, Szalai JP, Chan CK, Lipton JH, Messner HA, Laupacis A . Pulmonary function abnormalities after allogeneic marrow transplantation: a systematic review and assessment of an existing predictive instrument. Bone Marrow Transplant 2002; 30: 599–607.

    Article  CAS  PubMed  Google Scholar 

  2. Hasegawa W, Pond GR, Rifkind JT, Messner HA, Lau A, Daly AS et al. Long-term follow-up of secondary malignancies in adults after allogeneic bone marrow transplantation. Bone Marrow Transplant 2005; 35: 51–55.

    Article  CAS  PubMed  Google Scholar 

  3. Baker KS, DeFor TE, Burns LJ, Ramsay NK, Neglia JP, Robison LL . New malignancies after blood or marrow stem-cell transplantation in children and adults: incidence and risk factors. J Clin Oncol 2003; 21: 1352–1358.

    Article  PubMed  Google Scholar 

  4. Bhatia S, Louie AD, Bhatia R, O’Donnell MR, Fung H, Kashyap A et al. Solid cancer after bone marrow transplantation. J Clin Oncol 2001; 19: 464–471.

    Article  CAS  PubMed  Google Scholar 

  5. Curtis RE, Rowlings PA, Deeg HJ, Shriner DA, Socíe G, Travis LB et al. Solid cancer after bone marrow transplantation. N Engl J Med 1997; 336: 897–904.

    Article  CAS  PubMed  Google Scholar 

  6. Shimada K, Yokozawa T, Atsuta Y, Kohno A, Maruyama F, Yano K et al. Solid tumors after hematopoietic stem cell transplantation in Japan: incidence, risk factors and prognosis. Bone Marrow Transplant 2005; 36: 115–121.

    Article  CAS  PubMed  Google Scholar 

  7. Ahmad I, Cau NV, Kwan J, Maaroufi Y, Meuleman N, Aoun M et al. Preemptive management of Epstein-Barr virus reactivation after hematopoietic stem-cell transplantation. Transplantation 2009; 87: 1240–1245.

    Article  CAS  PubMed  Google Scholar 

  8. Landgren O, Gilbert ES, Rizzo JD, Socíe G, Banks PM, Sobocinski KA et al. Risk factors for lymphoproliferative disorders after allogeneic hematopoietic cell transplantation. Blood 2009; 113: 4992–5001.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Curtis RE, Metayer C, Rizzo JD, Socíe G, Sobocinski KA, Flowers ME et al. Impact of chronic GVHD therapy on the development of squamous-cell cancers after hematopoietic stem-cell transplantation: an international case-control study. Blood 2005; 105: 3802–3811.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Rugarli C, Smeraldi RS, Villa MG, Pello F . HL-A antigens in serum from bone marrow harvested for diagnostic purposes. Biomedicine 1976; 25: 100–104.

    CAS  PubMed  Google Scholar 

  11. Little AM, Marsh SG, Madrigal JA . Current methodologies of human leukocyte antigen typing utilized for bone marrow donor selection. Curr Opin Hematol 1998; 5: 419–428.

    Article  CAS  PubMed  Google Scholar 

  12. Rizzo JD, Curtis RE, Socié G, Sobocinski KA, Gilbert E, Landgren O et al. Solid cancers after allogeneic hematopoietic cell transplantation. Blood 2009; 113: 1175–1183.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Socié G, Curtis RE, Deeg HJ, Sobocinski KA, Filipovich AH, Travis LB et al. New malignant diseases after allogeneic marrow transplantation for childhood acute leukemia. J Clin Oncol 2000; 18: 348–357.

    Article  PubMed  Google Scholar 

  14. Ko YC, Huang YL, Lee CH, Chen MJ, Lin LM, Tsai CC . Betel quid chewing, cigarette smoking and alcohol consumption related to oral cancer in Taiwan. J Oral Pathol Med 1995; 24: 450–453.

    Article  CAS  PubMed  Google Scholar 

  15. D’Souza G, Kreimer AR, Viscidi R, Pawlita M, Fakhry C, Koch WM et al. Case-control study of human papillomavirus and oropharyngeal cancer. N Engl J Med 2007; 356: 1944–1956.

    Article  PubMed  Google Scholar 

  16. Fakhry C, Gillison ML . Clinical implications of human papillomavirus in head and neck cancers. J Clin Oncol 2006; 24: 2606–2611.

    Article  PubMed  Google Scholar 

  17. Savani BN, Goodman S, Barrett AJ . Can routine post-transplant HPV vaccination prevent commonly occurring epithelial cancers after allogeneic stem cell transplantation? Clin Cancer Res 2009; 15: 2219–2221.

    Article  CAS  PubMed  Google Scholar 

  18. Chen MH, Hsiao LT, Chiou TJ, Liu JH, Gau JP, Teng HW et al. High prevalence of occult hepatitis B virus infection in patients with B cell non-Hodgkin's lymphoma. Ann Hematol 2008; 87: 475–480.

    Article  PubMed  Google Scholar 

  19. Janin A, Murata H, Leboeuf C, Cayuela JM, Gluckman E, Legrès L et al. Donor-derived oral squamous cell carcinoma after allogeneic bone marrow transplantation. Blood 2009; 113: 1834–1840.

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgements

This work was partially supported by the Taiwan Clinical Oncology Research Foundation.

Author information

Authors and Affiliations

Authors

Corresponding authors

Correspondence to T J Chiou or C H Tzeng.

Ethics declarations

Competing interests

The authors declare no conflict of interest.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Chen, M., Chang, P., Li, W. et al. High incidence of oral squamous cell carcinoma independent of HPV infection after allogeneic hematopoietic SCT in Taiwan. Bone Marrow Transplant 46, 567–572 (2011). https://doi.org/10.1038/bmt.2010.163

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/bmt.2010.163

Keywords

This article is cited by

Search

Quick links