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Assignment of scores for the hematopoietic cell transplantation comorbidity index: integer vs exact weights

Bone Marrow Transplantation volume 46, pages 464–466 (2011)Cite this article

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In 2005, the hematopoietic cell transplantation comorbidity index (HCT-CI) was proposed as a tool to capture information on 17 different organ-specific comorbidities.1 Each of those 17 was independently associated with an increase in nonrelapse mortality (NRM) in a cohort of 708 Seattle patients with various hematologic malignancies who were treated with allogeneic HCT after either myeloablative or nonmyeloablative conditioning regimens, with the intent that the index would be broadly applicable across disease and treatment combinations.

To calculate the HCT-CI, the adjusted hazard ratios (HRs) for NRM were given integer weights.1 The HCT-CI score was the sum of these integer weights. The use of integer weights enabled the HCT-CI to be calculated easily and was consistent with other comorbidity indices used routinely in medicine. Further, integer weights would account for the ranges of variability in the HRs of comorbidities across different institutions and transplant strategies.

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References

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Acknowledgements

This study was supported by grants HL36444, CA78902, CA18029, CA15704 and HL088021 from the National Institutes of Health, Bethesda, MD. We thank Helen Crawford, Bonnie Larson, Karen Carbonneau and Sue Carbonneau for their assistance with manuscript preparation.

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Authors and Affiliations

  1. Fred Hutchinson Cancer Research Center, Seattle, WA, USA

    M L Sorror, B Storer & R Storb

  2. Department of Medicine, University of Washington School of Medicine, Seattle, WA, USA

    M L Sorror & R Storb

  3. Department of Biostatistics, University of Washington School of Public Health, Seattle, WA, USA

    B Storer

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  1. M L Sorror
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  2. B Storer
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Correspondence to M L Sorror.

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Sorror, M., Storer, B. & Storb, R. Assignment of scores for the hematopoietic cell transplantation comorbidity index: integer vs exact weights. Bone Marrow Transplant 46, 464–466 (2011). https://doi.org/10.1038/bmt.2010.131

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