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Post-Transplant Events

Low risk of symptomatic venous thromboembolic events during growth factor administration for PBSC mobilization

Bone Marrow Transplantation volume 46, pages 291–293 (2011)Cite this article

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Abstract

The use of erythropoietic agents has been associated with an increased risk of venous thromboembolic events (VTEs), especially in patients with underlying malignancies. However, it is not known whether there is an increased risk of VTE associated with granulocyte growth factors. We reviewed 621 patients undergoing PBSC mobilization using granulocyte growth factors, alone or in combination with CY. Patients with a diagnosis of AL amyloidosis (AL: 114; 18%), multiple myeloma (MM: 278; 44%) Hodgkin lymphoma (HL: 20; 3%) or non-Hodgkin lymphoma (NHL: 209; 33%) were included. Symptomatic VTE occurred in six (0.97%) patients: two AL, two MM and two NHL. Of the six patients, two had pulmonary embolism, one developed deep vein thrombosis and three developed symptomatic catheter related thrombosis. Two patients with AL had heparin-induced thrombocytopenia and thrombosis. We found a low incidence of VTE among patients undergoing PBSC mobilization.

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Authors and Affiliations

  1. Division of Hematology and Internal Medicine, Mayo Clinic, Rochester, MN, USA

    H V Naina, R K Pruthi, D J Inwards, D Dingli, M R Litzow, S M Ansell, H J William, A Dispenzieri, F K Buadi, M A Elliott, D A Gastineau, M A Gertz, S R Hayman, P B Johnston, M Q Lacy, I N Micallef, L F Porrata & S Kumar

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  1. H V Naina
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  2. R K Pruthi
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  3. D J Inwards
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  6. S M Ansell
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  7. H J William
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  8. A Dispenzieri
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  9. F K Buadi
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  10. M A Elliott
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  13. S R Hayman
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  14. P B Johnston
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  15. M Q Lacy
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  16. I N Micallef
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  17. L F Porrata
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  18. S Kumar
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Correspondence to S Kumar.

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Naina, H., Pruthi, R., Inwards, D. et al. Low risk of symptomatic venous thromboembolic events during growth factor administration for PBSC mobilization. Bone Marrow Transplant 46, 291–293 (2011). https://doi.org/10.1038/bmt.2010.106

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  • DOI: https://doi.org/10.1038/bmt.2010.106

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