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Allografting

Prognostic factors and outcome in relapsed multiple myeloma after nonmyeloablative allo-SCT: a single center experience

Bone Marrow Transplantation volume 46, pages 244–249 (2011)Cite this article

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Abstract

For relapsed multiple myeloma (MM) patients, allo-SCT is a possible treatment option, but recent data obtained using a nonmyeloablative (NMA) conditioning regimen are scarce. We retrospectively collected data from 38 relapsed MM patients who received a NMA allo-SCT from October 2001 to January 2008. In total, 18 patients (48%) were transplanted using a matched unrelated donor. The median follow-up is 2.3 years. In 16 patients (42%) the response improved and eight patients (21%) were rapidly progressive within 6 months after allo-SCT. In total, 15 patients (39%) were in CR after allo-SCT. The median PFS was 1.4 years (range, 0.1–4.9), and having a CR after allo-SCT or having chronic GVHD resulted in longer PFS. Median OS was 3.1 years (range, 0.2–7.2) and again having a CR after allo-SCT or chronic GVHD was associated with a better OS. Six patients (16%) have died from treatment-related diseases. These results indicate that NMA allo-SCT is a treatment option in relapsed MM patients and that results may be improved by strategies that enhance the CR rate after allo-SCT.

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Authors and Affiliations

  1. Department of Hematology, UMC Utrecht, Utrecht, The Netherlands

    M C Minnema, N W C J van de Donk, F Schouten & H M Lokhorst

  2. Department of Immunology, UMC Utrecht, Utrecht, The Netherlands

    S van Dorp

  3. Department of Hematology, AMC, Amsterdam, The Netherlands

    M J Kersten

  4. Department of Internal Medicine, Isala Klinieken, Zwolle, The Netherlands

    J L L M Coenen

  5. Department of Internal Medicine, UHM, Maastricht, The Netherlands

    H Schouten

  6. Department of Hematology, VU UMC, Amsterdam, The Netherlands

    S Zweegman

  7. Department of Internal Medicine, MST, Enschede, The Netherlands

    R Schaafsma

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  1. M C Minnema
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Correspondence to M C Minnema.

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Minnema, M., van Dorp, S., van de Donk, N. et al. Prognostic factors and outcome in relapsed multiple myeloma after nonmyeloablative allo-SCT: a single center experience. Bone Marrow Transplant 46, 244–249 (2011). https://doi.org/10.1038/bmt.2010.101

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  • DOI: https://doi.org/10.1038/bmt.2010.101

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