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History of cord blood transplantation

Bone Marrow Transplantation volume 44, pages 621–626 (2009)Cite this article

Abstract

Since the first human cord blood transplant, performed 20 years ago, cord blood banks have been established worldwide for the collection and cryopreservation of cord blood for allogeneic hematopoietic stem cell transplant. A global network of cord blood banks and transplant centers has been established for a common inventory and study of clinical outcomes. Results of unrelated allogeneic cord blood transplants in malignant and nonmalignant diseases, in adults and children, show that, compared with HLA-matched unrelated BM transplant, cord blood has several advantages, including prompt availability of the transplant, decrease of GVHD and better long-term immune recovery resulting in a similar long-term survival. Several studies have shown that the number of cells is the most important factor for engraftment, although some degree of HLA mismatches is acceptable. Developments are expected to facilitate engraftment, including ex vivo expansion of stem cells, intrabone injection of cord blood cells and double cord blood transplants. In addition to hematopoietic stem cells, cord blood and placenta contain a large number of nonhematopoietic stem cells. In the absence of ethical concern, the unlimited supply of cells explains the increasing interest of using cord blood for developing regenerative medicine.

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References

  1. Auerbach AD, Liu O, Ghosh R, Pollack MS, Douglas GW, Broxmeyer HE . Prenatal identification of potential donors for umbilical cord blood transplantation for Fanconi anemia. Transfusion 1990; 30: 682–687.

    Article  CAS  Google Scholar 

  2. Broxmeyer HE, Gordon GW, Hangoc G, Cooper S, Bard J, English D et al. Human umbilical cord blood as a potential source of transplantable hematopoietic stem/progenitor cells. Proc Natl Acad Sci USA 1989; 86: 3828–3832.

    Article  CAS  Google Scholar 

  3. Gluckman E, Devergie A, Dutreix J . Radio sensitivity in Fanconi anemia: application to the conditioning regimen for bone marrow transplantation. Br J Haematol 1983; 54: 431–440.

    Article  CAS  Google Scholar 

  4. Linch DC, Knott LJ, Rodeck CH, Huehns CH . Studies of circulating hematopoietic progenitor cells in human fetal blood. Blood 1982; 59: 976–979.

    CAS  PubMed  Google Scholar 

  5. Forestier F, Daffos F, Catherine N, Renard M, Andreux JP . Developmental hematopoiesis in normal human fetal blood. Blood 1991; 77: 2360–2363.

    CAS  PubMed  Google Scholar 

  6. Harrison MR, Slotnick RN, Crombleholme TM, Golbus MS, Tarantal AF, Zanjani ED . In utero transplantation of fetal liver haemopoietic stem cells in monkeys. The Lancet 1989; ii: 1425–1427.

    Article  Google Scholar 

  7. Broxmeyer HE, Hangoc G, Cooper S, Ribeiro RC, Graves V, Yoder M et al. Growth characteristics and expansion of human umbilical cord blood and estimation of its potential for transplantation in adults. Proc Natl Acad Sci USA 1992; 89: 4109–4113.

    Article  CAS  Google Scholar 

  8. Gluckman E, Broxmeyer HE, Auerbach AD, Friedman HS, Douglas GW, Devergie A et al. Hematopoietic reconstitution in a patient with Fanconi ‘s anemia by means of umbilical cord blood from an HLA-identical sibling. New Engl J Med 1989; 321: 1174–1178.

    Article  CAS  Google Scholar 

  9. Linch DC, Brent L . Can cord blood be used? Nature 1989; 340: 676.

    Article  CAS  Google Scholar 

  10. Nathan DG . The beneficence of neonatal hematopoiesis. New Engl J Med 1982; 321: 1190.

    Article  Google Scholar 

  11. Griffiths-Chu S, Patterson JAK, Berger CL, Edelson RL, Chu AC . Characterization of immature T cell subpopulations in neonatal blood. Blood 1984; 64: 296–300.

    CAS  PubMed  Google Scholar 

  12. Durandy A, Thuillier L, Forveille M, Fischer A . Phenotypic and functional characteristics of human newborns B lymphocytes. J Immunol 1990; 144: 60–65.

    CAS  PubMed  Google Scholar 

  13. Rubinstein P, Rosenfield RD, Adamson JW, Stevens CE . Stored placental blood for unrelated bone marrow reconstitution. Blood 1993; 81: 1679–1690.

    CAS  PubMed  Google Scholar 

  14. Rubinstein P, Dobrila L, Rosenfield RE, Adamson JW, Migliaccio G, Migliaccio AR et al. Processing and cryopreservation of placental/ umbilical cord blood for unrelated bone marrow reconstitution. Proc Natl Acad Sci USA 1995; 92: 10119–10122.

    Article  CAS  Google Scholar 

  15. Wernet PW . The international NETCORD Foundation in Cord blood. Broxmeyer HE (eds). Biology Immunology, Banking and Clinical Transplantation. AABB Press: Bethesda, MD, 2004, pp 429–435.

    Google Scholar 

  16. Kurtzberg J, Laughlin M, Graham ML, Smith C, Olson JF, Halperin EC et al. Placental blood as a source of hematopoietic stem cells for transplantation into unrelated recipients. New Engl J Med 1996; 335: 157–166.

    Article  CAS  Google Scholar 

  17. Laporte JP, Gorin NC, Rubinstein P, Lesage S, Portnoi MF, Barbu V et al. Cord blood transplantation from an unrelated donor in an adult with chronic myelogenous leukemia. New Engl J Med 1996; 335: 167–170.

    Article  CAS  Google Scholar 

  18. Gluckman E, Rocha V, Boyer Chammard A, Locatelli F, Arcese W, Pasquini R et al. Outcome of cord blood transplantation from related and unrelated donors. New Engl J Med 1997; 337: 373–381.

    Article  CAS  Google Scholar 

  19. Wagner JE, Kernan NA, Steinbuch M, Broxmeyer HE, Gluckman E . Allogeneic sibling cord blood transplantation in forty four children with malignant and non malignant disease. Lancet 1995; 346: 214–219.

    Article  CAS  Google Scholar 

  20. Wagner JE, Rosenthal J, Sweetman R, Shu XO, Davies SM, Ramsay NK et al. Successful transplantation of HLA Matched and HLA mismatched umbilical cord blood from unrelated donors: analysis of engraftment and acute graft versus host disease. Blood 1996; 88: 795–802.

    CAS  PubMed  Google Scholar 

  21. Rubinstein P, Carrier C, Scaradavou A, Kurtzberg J, Adamson J, Migliaccio AR et al. Outcomes among 562 recipients of placental-blood transplants from unrelated donors. New Engl J Med 1998; 339: 1565–1577.

    Article  CAS  Google Scholar 

  22. Laughlin MJ, Barker J, Bambach B, Koc ON, Rizzieri DA, Wagner JE et al. Hematopoietic engraftment and survival in adult recipients of umbilical-cord blood from unrelated donors. N Engl J Med 2001; 344: 1815–1822.

    Article  CAS  Google Scholar 

  23. Wagner JE, Barker JN, DeFor TE, Baker KS, Blazar BR, Eide C et al. Transplantation of unrelated donor umbilical cord blood in 102 patients with malignant and non malignant diseases: influence of CD34 cell dose and HLA disparity on treatment-related mortality and survival. Blood 2002; 100: 1611–1618.

    CAS  PubMed  Google Scholar 

  24. Gluckman E, Rocha V, Arcese W, Michel G, Sanz G, Chan KW et al. on behalf of Eurocord group Factors Associated with Outcome of Unrelated Cord Blood Transplant: Guidelines for Donor Choice. Exp Hematol 2004; 32: 397–407.

    Article  CAS  Google Scholar 

  25. Rocha V, Wagner JE, Sobocinski K, Klein JP, Zhang MJ, Horowitz MM et al. Comparison of graft-versus-host disease in children transplanted with HLA identical sibling umbilical cord blood versus HLA identical sibling bone marrow transplant. New Engl J Med 2000; 342: 1846–1854.

    Article  CAS  Google Scholar 

  26. Rocha V, Cornish J, Sievers E, Filipovich A, Locatelli F, Peters C et al. Comparison of outcomes of unrelated bone marrow and umbilical cord blood transplants in children with acute leukemia. Blood 2001; 97: 2962–2971.

    Article  CAS  Google Scholar 

  27. Rocha V, Labopin M, Sanz G, Arcese W, Schwerdtfeger R, Bosi et al. for the Acute Leukemia Working Party of European Blood and Marrow Transplant group and Eurocord-Netcord registry. Comparison of outcomes after unrelated umbilical cord versus unrelated bone marrow transplants in adults with acute leukemia. New Engl J Med 2004; 351: 2276–2285.

    Article  CAS  Google Scholar 

  28. Laughlin MJ, Eapen M, Rubinstein P, Wagner JE, Zhang MJ, Champlin RE et al. Outcomes after transplantation of cord blood or bone marrow from unrelated donors in adults with leukemia. N Engl J Med 2004; 351: 2265–2275.

    Article  CAS  Google Scholar 

  29. Takahashi S, Ooi J, Tomonari A, Konuma T, Tsukada N, Oiwa-Monna M et al. Comparative single-institute analysis of cord blood transplantation from unrelated donors with bone marrow or peripheral blood stem-cell transplants from related donors in adult patients with hematologic malignancies after myeloablative conditioning regimen. Blood 2007; 109: 1322–1330.

    Article  CAS  Google Scholar 

  30. Ballen KK, Spitzer TR, Yeap BY, McAfee S, Dey BR, Attar E et al. Double unrelated reduced-intensity umbilical cord blood transplantation in adults. Biol Blood Marrow Transplant 2007; 13: 82–89.

    Article  CAS  Google Scholar 

  31. Barker JN, Weisdorf DJ, DeFor TE, Blazar BR, Miller JS, Wagner JE . Rapid and complete donor chimerism in adult recipients of unrelated donor umbilical cord blood transplantation after reduced-intensity conditioning. Blood 2003; 102: 1915–1919.

    Article  CAS  Google Scholar 

  32. Querol S, Mufti GJ, Marsh SGE, Pagliuca A, Little AM, Shaw BE et al. Cord blood stem cells for hematopoietic stem cell transplantation in the UK: how big should the bank be? Haematologica 2009; 94: 536–541.

    Article  Google Scholar 

  33. Hwang WY, Samuel M, Tan D, Koh LP, Lim W, Linn YC . A Meta-Analysis of Unrelated Donor Umbilical Cord Blood Transplantation versus Unrelated Donor Bone Marrow Transplantation in Adult and Pediatric Patients. Biol Blood Marrow Transplant 2007; 13: 444–453.

    Article  Google Scholar 

  34. Locatelli F, Rocha V, Chastang C, Arcese W, Michel G, Abecasis M et al. Factors associated with outcome after cord blood transplantation in children with acute leukemia. Blood 1999; 93: 3662–3667.

    CAS  PubMed  Google Scholar 

  35. Cairo MS, Wagner JE . Placental and/or umbilical cord blood an alternative source of haemopoietic stem cells for transplantation. Blood 1997; 90: 4665–4678.

    CAS  PubMed  Google Scholar 

  36. Sanz GF, Saavedra S, Planelles D, Senent L, Cervera J, Barragán E et al. Standardized, unrelated donor cord blood transplantation in adults with hematological malignancies. Blood 2001; 98: 2332–2338.

    Article  CAS  Google Scholar 

  37. Eapen M, Rubinstein P, Zhang MJ, Stevens C, Kurtzberg J, Scaradavou A et al. Outcomes of transplantation of unrelated donor umbilical cord blood and bone marrow in children with acute leukemia: a comparison study. Lancet 2007; 369: 1947–1954.

    Article  Google Scholar 

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  1. Eurocord, Hospital Saint Louis, and University Paris VII, Paris, France

    E Gluckman

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Correspondence to E Gluckman.

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Gluckman, E. History of cord blood transplantation. Bone Marrow Transplant 44, 621–626 (2009). https://doi.org/10.1038/bmt.2009.280

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