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Autografting

Characterization of hemopoietic engraftment kinetics and development of secondary cytopenia in AML post auto-SCT and its correlation with survival outcome

Bone Marrow Transplantation volume 44, pages 175–183 (2009)Cite this article

Abstract

We performed a single center retrospective analysis of 84 autologous hemopoietic stem cell transplants done for AML to characterize the pattern of hemopoietic engraftment, post-transplant cytopenia and their impact on survival outcome. Following autologous transplant and engraftment, 30 patients (35.7%) had a transient secondary decline in their plt counts, which was not associated with graft rejection, relapse or infection. The median time to onset of thrombocytopenia was 59 days post transplant, with spontaneous recovery after a median period of 41 days. A secondary decline in ANC also occurred in eight patients. Patients with secondary plt decline had a significantly earlier primary plt engraftment (median 15 days) and a trend towards earlier neutrophil engraftment compared with patients who maintained steady plt counts (median 21 days). There was a trend towards a lower incidence of secondary plt decline in patients who received BM stem cells compared with those who received PBSC. No cause was evident for the occurrence of a secondary cytopenia, and it did not adversely affect survival. We conclude that secondary cytopenia is a common and harmless occurrence after autologous transplant especially from PBSC graft.

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Acknowledgements

Dr Babatunde acknowledges the support provided by the University of Ilorin Teaching Hospital, Ilorin, Nigeria and the Postgraduate Medical Institute (PGMI), Singapore General Hospital, for the Clinical Fellowship in Bone Marrow Transplantation at the Department of Haematology, Singapore General Hospital. We would like to thank the research coordinators Ms Valerie Wee and Ms Perumal Premalatha for their assistance in providing the data, and the nursing and paramedical staff in the Department of Haematology for their excellent work in patient care. This study is supported by the Singapore Cancer Syndicate Grant for Bone Marrow Transplant Consortium Registry.

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Authors and Affiliations

  1. Department of Haematology, University of Ilorin, Ilorin, Kwara State, Nigeria

    A S Babatunde

  2. Department of Hematology, Singapore General Hospital, Singapore

    A S Babatunde, D C L Tan, K K Heng, J J Lee, Y S M Loh, W Y K Hwang, M B C Koh, Y T Goh & Y C Linn

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Babatunde, A., Tan, D., Heng, K. et al. Characterization of hemopoietic engraftment kinetics and development of secondary cytopenia in AML post auto-SCT and its correlation with survival outcome. Bone Marrow Transplant 44, 175–183 (2009). https://doi.org/10.1038/bmt.2009.1

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