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Can etoposide infusion during stem cell transplantation produce a febrile reaction mimicking bacterial sepsis?

Bone Marrow Transplantation volume 42, pages 59–60 (2008)Cite this article

Fever is an uncommon finding during the preparative regimen of SCT.1, 2 Nevertheless, we observed that some of our patients, mainly those who received shorter infusions of high-dose etoposide, developed fever a few hours later, and this led us to suspect and rule out infectious complications.

Etoposide is a frequently used drug in different schedules for different malignancies and, when conventional doses are administered, fever is not a commonly observed adverse effect.

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Authors and Affiliations

  1. Department of Pediatric Oncology, Children's Hospital ‘La Fe’, Valencia, Spain

    L Moreno, M M Andres, A Verdeguer, O Alvarez, J M Fernández-Navarro & M Fernández-Sanmartin

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  1. L Moreno
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  2. M M Andres
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  3. A Verdeguer
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  4. O Alvarez
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  5. J M Fernández-Navarro
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  6. M Fernández-Sanmartin
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Correspondence to A Verdeguer.

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Moreno, L., Andres, M., Verdeguer, A. et al. Can etoposide infusion during stem cell transplantation produce a febrile reaction mimicking bacterial sepsis?. Bone Marrow Transplant 42, 59–60 (2008). https://doi.org/10.1038/bmt.2008.75

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