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Infectious Diseases

Rare viral infections in children receiving hemopoietic stem cell transplant

Bone Marrow Transplantation volume 41, pages S100–S103 (2008)Cite this article

Abstract

Viral infections are a rare complication in autologous hemopoietic stem cell transplant (HSCT) recipients but represent a frequent cause of disease after allogeneic HSCT. In the last years, there has been an increase in the number of viral diseases observed in these patients. This fact may be at least partially due to an improvement in diagnostic facilities, but the increasing number of transplant procedures and the more severe immunosuppression may also have played an important role.

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References

  1. Sepkowitz KA . Risk and epidemiology of infections after allogeneic hemopoietic stem cell transplantation. In: Bowden RA, Ljungman P, Paya CV (eds). Transplant Infections. Lippincott Willians & Wilkins: Philadelphia, 2003, pp 31–38.

    Google Scholar 

  2. Deeg HJ, Bowden RA . Introduction to hemopoietic stem cell transplantation. In: Bowden RA, Ljungman P, Paya CV (eds). Transplant Infections. Lippincott Willians & Wilkins: Philadelphia, 2003, pp 3–16.

    Google Scholar 

  3. Boeckh M, Erard V, Zerr D, Englund J . Emerging viral infections after hematopoietic cell transplantation. Pediatr Transplant 2005; 9: 48–54.

    Article  Google Scholar 

  4. Asano Y, Yoshikawa T, Suga S, Nakashima T, Yazaki T, Fukuda M et al. Reactivation of herpesvirus type 6 in children receiving bone marrow transplants for leukemia. N Engl J Med 1991; 324: 634–635.

    CAS  PubMed  Google Scholar 

  5. Castagnola E, Cappelli B, Erba D, Rabagliati A, Lanino E, Dini G . Cytomegalovirus infection after bone marrow transplantation in children. Hum Immunol 2004; 65: 416–422.

    Article  Google Scholar 

  6. Carrega G, Castagnola E, Canessa A, Argenta P, Haupt R, Dini G et al. Herpes simplex virus and oral mucositis in children with cancer. Support Care Cancer 1994; 2: 266–269.

    Article  CAS  Google Scholar 

  7. Castagnola E, Dallorso S, Rabagliati M, Sacco O, Kotitsa Z, Dini G . Survival after cytomegalovirus pneumonia in two children receiving autologous peripheral blood progenitor cell transplantation (PBPCT). Bone Marrow Transplant 1998; 21: 529–531.

    Article  CAS  Google Scholar 

  8. Troussard X, Bauduer F, Gallet E, Freymuth F, Boutard P, Ballet JJ et al. Virus recovery from stools of patients undergoing bone marrow transplantation. Bone Marrow Transplant 1993; 12: 573–576.

    CAS  Google Scholar 

  9. Rayani A, Bode U, Habas E, Fleischhack G, Engelhart S, Exner M et al. Rotavirus infections in paediatric oncology patients: a matched-pairs analysis. Scand J Gastroenterol 2007; 42: 81–87.

    Article  Google Scholar 

  10. Krajden M, Brown M, Petrasek A, Middleton PJ . Clinical features of adenovirus enteritis: a review of 127 cases. Pediatr Infect Dis J 1990; 9: 636–641.

    CAS  PubMed  Google Scholar 

  11. Goodgame R . Norovirus gastroenteritis. Curr Infect Dis Rep 2007; 9: 102–109.

    Article  Google Scholar 

  12. Simon A, Schildgen O, Maria Eis-Hübinger A, Hasan C, Bode U, Buderus S et al. Norovirus outbreak in a pediatric oncology unit. Scand J Gastroenterol 2006; 41: 693–699.

    Article  Google Scholar 

  13. Viscoli C, Castagnola E, Rogers D . Infections in the compromised child. Baillieres Clin Haematol 1991; 4: 511–543.

    Article  CAS  Google Scholar 

  14. Savolainen H, Lautenschlager I, Piiparinen H, Saarinen-Pihkala U, Hovi L, Vettenranta K . Human herpesvirus-6 and -7 in pediatric stem cell transplantation. Pediatr Blood Cancer 2005; 45: 820–825.

    Article  Google Scholar 

  15. Yoshikawa T . Human herpesvirus-6 and -7 infections in transplantation. Pediatr Transplant 2003; 7: 11–17.

    Article  CAS  Google Scholar 

  16. Chan PK, Li CK, Chik KW, Lee V, Shing MM, Ng KC et al. Risk factors and clinical consequences of human herpesvirus 7 infection in paediatric haematopoietic stem cell transplant recipients. J Med Virol 2004; 72: 668–674.

    Article  Google Scholar 

  17. Small TN, Casson A, Malak SF, Boulad F, Kiehn TE, Stiles J et al. Respiratory syncytial virus infection following hematopoietic stem cell transplantation. Bone Marrow Transplant 2002; 29: 321–327.

    Article  CAS  Google Scholar 

  18. Yoshikawa T, Fujita A, Yagami A, Suzuki K, Matsunaga K, Ihira M et al. Human herpesvirus 6 viremia in bone marrow transplant recipients: clinical features and risk factors. J Infect Dis 2002; 185: 847–853.

    Article  Google Scholar 

  19. Chan PK, Chik KW, To KF, Li CK, Shing MM, Ng KC et al. Case report: human herpesvirus 7 associated fatal encephalitis in a peripheral blood stem cell transplant recipient. J Med Virol 2002; 66: 493–496.

    Article  Google Scholar 

  20. Khanani M, Al-Ahmari A, Tellier R, Allen U, Richardson S, Doyle JJ et al. Human herpesvirus 7 in pediatric hematopoietic stem cell transplantation. Pediatr Blood Cancer 2007; 48: 567–570.

    Article  Google Scholar 

  21. Carbone A, Gloghini A . HHV-8-associated lymphoma: state-of-the-art review. Acta Haematol 2007; 117: 129–131.

    Article  Google Scholar 

  22. Viejo-Borbolla A, Ottinger M, Schulz TF . Human herpesvirus 8: biology and role in the pathogenesis of kaposi's sarcoma and other AIDS-related malignancies. Curr Infect Dis Rep 2003; 5: 169–175.

    Article  Google Scholar 

  23. Tan HH, Goh CL . Viral infections affecting the skin in organ transplant recipients: epidemiology and current management strategies. Am J Clin Dermatol 2006; 7: 13–29.

    Article  Google Scholar 

  24. de Medeiros BC, Rezuke WN, Ricci A, Tsongalis G, Shen PU, Bona RD et al. Kaposi's sarcoma following allogeneic hematopoietic stem cell transplantation for chronic myelogenous leukemia. Acta Haematol 2000; 104: 115–118.

    Article  CAS  Google Scholar 

  25. Gentile G, Capobianchi A, Volpi A, Palù G, Pica F, Calistri A et al. Human herpesvirus 8 DNA in serum during seroconversion in allogeneic bone marrow transplant recipients. J Natl Cancer Inst 2005; 97: 1008–1011.

    Article  CAS  Google Scholar 

  26. Erard V, Kim HW, Corey L, Limaye A, Huang ML, Myerson D et al. BK DNA viral load in plasma: evidence for an association with hemorrhagic cystitis in allogeneic hematopoietic cell transplant recipients. Blood 2005; 106: 1130–1132.

    Article  CAS  Google Scholar 

  27. Bogdanovic G, Priftakis P, Giraud G, Kuzniar M, Ferraldeschi R, Kokhaei P et al. Association between a high BK virus load in urine samples of patients with graft-versus-host disease and development of hemorrhagic cystitis after hematopoietic stem cell transplantation. J Clin Microbiol 2004; 42: 5394–5396.

    Article  CAS  Google Scholar 

  28. Childs R, Sanchez C, Engler H, Preuss J, Rosenfeld S, Dunbar C et al. High incidence of adeno- and polyomavirus-induced hemorrhagic cystitis in bone marrow allotransplantation for hematological malignancy following T cell depletion and cyclosporine. Bone Marrow Transplant 1998; 22: 889–893.

    Article  CAS  Google Scholar 

  29. Akiyama H, Kurosu T, Sakashita C, Inoue T, Mori Si, Ohashi K et al. Adenovirus is a key pathogen in hemorrhagic cystitis associated with bone marrow transplantation. Clin Infect Dis 2001; 32: 1325–1330.

    Article  CAS  Google Scholar 

  30. Tutuncuoglu SO, Yanovich S, Ozdemirli M . CMV-induced hemorrhagic cystitis as a complication of peripheral blood stem cell transplantation: case report. Bone Marrow Transplant 2005; 36: 265–266.

    Article  CAS  Google Scholar 

  31. Bielorai B, Shulman LM, Rechavi G, Toren A . CMV reactivation induced BK virus-associated late onset hemorrhagic cystitis after peripheral blood stem cell transplantation. Bone Marrow Transplant 2001; 28: 613–614.

    Article  CAS  Google Scholar 

  32. Spach DH, Bauwens JE, Myerson D, Mustafa MM, Bowden RA . Cytomegalovirus-induced hemorrhagic cystitis following bone marrow transplantation. Clin Infect Dis 1993; 16: 142–144.

    Article  CAS  Google Scholar 

  33. Freim Wahl SG, Folvik MR, Torp SH . Progressive multifocal leukoencephalopathy in a lymphoma patient with complete remission after treatment with cytostatics and rituximab: case report and review of the literature. Clin Neuropathol 2007; 26: 68–73.

    Article  CAS  Google Scholar 

  34. Goldberg SL, Pecora AL, Alter RS, Kroll MS, Rowley SD, Waintraub SE et al. Unusual viral infections (progressive multifocal leukoencephalopathy and cytomegalovirus disease) after high-dose chemotherapy with autologous blood stem cell rescue and peritransplantation rituximab. Blood 2002; 99: 1486–1488.

    Article  CAS  Google Scholar 

  35. Heegaard ED, Brown KE . Human parvovirus B19. Clin Microbiol Rev 2002; 15: 485–505.

    Article  Google Scholar 

  36. Young NS, Brown KE . Parvovirus B19. N Engl J Med 2004; 350: 586–597.

    Article  CAS  Google Scholar 

  37. Broliden K . Parvovirus B19 infection in pediatric solid-organ and bone marrow transplantation. Pediatr Transplant 2001; 5: 320–330.

    Article  CAS  Google Scholar 

  38. Plentz A, Hahn J, Holler E, Jilg W, Modrow S . Long-term parvovirus B19 viraemia associated with pure red cell aplasia after allogeneic bone marrow transplantation. J Clin Virol 2004; 31: 16–19.

    Article  Google Scholar 

  39. Cane PA, van den Hoogen BG, Chakrabarti S, Fegan CD, Osterhaus AD . Human metapneumovirus in a haematopoietic stem cell transplant recipient with fatal lower respiratory tract disease. Bone Marrow Transplant 2003; 31: 309–310.

    Article  CAS  Google Scholar 

  40. Debiaggi M, Canducci F, Sampaolo M, Marinozzi MC, Parea M, Terulla C et al. Persistent symptomless human metapneumovirus infection in hematopoietic stem cell transplant recipients. J Infect Dis 2006; 194: 474–478.

    Article  Google Scholar 

  41. Locasciulli A, Nava S, Sparano P, Testa M . Infections with hepatotropic viruses in children treated with allogeneic bone marrow transplantation. Bone Marrow Transplant 1998; 21 (Suppl 2): S75–S77.

    PubMed  Google Scholar 

  42. Hamaguchi M, Yamada H, Gondo H, Takemoto Y, Morishima Y, Kodera Y . Retrospective study on the impact of hepatitis B and hepatitis C virus infection on hematopoietic stem cell transplantation in Japan. Int J Hematol 2002; 75: 324–331.

    Article  Google Scholar 

  43. Uhm JE, Kim K, Lim TK, Park BB, Park S, Hong YS et al. Changes in serologic markers of hepatitis B following autologous hematopoietic stem cell transplantation. Biol Blood Marrow Transplant 2007; 13: 463–468.

    Article  CAS  Google Scholar 

  44. Maruta A, Kanamori H, Fukawa H, Harano H, Matsuzaki M, Miyashita H et al. Liver function tests of recipients with hepatitis C virus infection after bone marrow transplantation. Bone Marrow Transplant 1994; 13: 417–422.

    CAS  PubMed  Google Scholar 

  45. Kanamori H, Fukawa H, Maruta A, Harano H, Kodama F, Matsuzaki M et al. Case report: fulminant hepatitis C viral infection after allogeneic bone marrow transplantation. Am J Med Sci 1992; 303: 109–111.

    Article  CAS  Google Scholar 

  46. Kitano K, Kobayashi H, Hanamura M, Furuta K, Ueno M, Rokuhara A et al. Fulminant hepatitis after allogenic bone marrow transplantation caused by reactivation of hepatitis B virus with gene mutations in the core promotor region. Eur J Haematol 2006; 77: 255–258.

    Article  CAS  Google Scholar 

  47. Locasciulli A, Bruno B, Alessandrino EP, Meloni G, Arcese W, Bandini G et al. Hepatitis reactivation and liver failure in haemopoietic stem cell transplants for hepatitis B virus (HBV)/hepatitis C virus (HCV) positive recipients: a retrospective study by the Italian group for blood and marrow transplantation. Bone Marrow Transplant 2003; 31: 295–300.

    Article  CAS  Google Scholar 

  48. Fioredda F, Gigliotti AR, Haupt R, Calevo MG, Giudice CL, Bocciardo L et al. HCV infection in very-long-term survivors after cancer chemotherapy and bone marrow transplantation: a single-center experience. J Pediatr Hematol Oncol 2005; 27: 481–485.

    Article  Google Scholar 

  49. Maruta A, Tanabe J, Hashimoto C, Kato K, Kanamori H, Fukawa H et al. Long-term liver function of recipients with hepatitis G virus infection after bone marrow transplantation. Bone Marrow Transplant 1999; 24: 359–363.

    Article  CAS  Google Scholar 

  50. Corbi C, Traineau R, Esperou H, Ravera N, Portelette E, Benbunan M et al. Prevalence and clinical features of hepatitis G virus infection in bone marrow allograft recipients. Bone Marrow Transplant 1997; 20: 965–968.

    Article  CAS  Google Scholar 

  51. Rodriguez-Iñigo E, Tomás JF, Gómez-García de Soria V, Bartolomé J, Pinilla I, Amaro MJ et al. Hepatitis C and G virus infection and liver dysfunction after allogeneic bone marrow transplantation: results from a prospective study. Blood 1997; 90: 1326–1331.

    PubMed  Google Scholar 

  52. Tasso L, Castagnola E, Lo Giudice C, Torre F, Micalizzi C, Picciotto A et al. Prospective evaluation of primary infection due to HCV, HGV or TTV in children with newly diagnosed neoplasia. Haematologica 2001; 86: 761–762.

    CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Hematology and Oncology, Infectious Diseases Unit, G Gaslini Children Hospital, Genoa, Italy

    E Castagnola, C Moroni & A R Natalizia

  2. Department of Hematology and Oncology, Bone Marrow Transplant Unit, G Gaslini Children Hospital, Genoa, Italy

    M Faraci, V de Fazio, G Morreale, E Lanino & G Dini

  3. Laboratory of Virology, G Gaslini Children Hospital, Genoa, Italy

    E Di Marco, C Cirillo, A M Rabagliati & R Ricci

  4. Service of Radiology, G Gaslini Children Hospital, Genoa, Italy

    C Granata

  5. Epidemiology and Biostatistics Section, Scientific Directorate, G Gaslini Children Hospital, Genoa, Italy

    R Haupt

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  1. E Castagnola
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  3. C Moroni
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Correspondence to E Castagnola.

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Castagnola, E., Faraci, M., Moroni, C. et al. Rare viral infections in children receiving hemopoietic stem cell transplant. Bone Marrow Transplant 41 (Suppl 2), S100–S103 (2008). https://doi.org/10.1038/bmt.2008.65

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