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Autografting

The relationship between absolute lymphocyte count with PFS in patients with Hodgkin's lymphoma undergoing autologous hematopoietic cell transplant

Bone Marrow Transplantation volume 42, pages 29–34 (2008)Cite this article

Abstract

Previous reports in Hodgkin's lymphoma (HL) patients undergoing autologous hematopoietic cell transplantation (AHCT) have demonstrated a significant association between the absolute lymphocyte count at day 15 (ALC-15) with survival. To evaluate this finding further, we analyzed 146 patients with relapsed/refractory HL who underwent AHCT to evaluate the relationship between lymphocyte counts at apheresis and at two time points (days 15 and 90) after AHCT with PFS. We found no association between the ALC-15 and the ALC-90 with PFS. We found lymphocyte counts at apheresis and disease sensitive to salvage chemotherapy were predictive of PFS. In conclusion, our study does provide some support for the theory that the immune system may be important in disease control but further and more detailed studies in this area are required.

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Acknowledgements

T Seshadri thanks the Haematology Society of Australia and New Zealand for financial support of her fellowship. Armand Keating holds the Gloria and Seymour Epstein Chair in Cell Therapy and Transplantation.

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Authors and Affiliations

  1. Autologous Blood and Marrow Transplant Programme, Princess Margaret Hospital, University of Toronto, Toronto, Ontario, Canada

    T Seshadri, A Keating, M Crump & J Kuruvilla

  2. Biostatistics Department, Princess Margaret Hospital, University of Toronto, Toronto, Ontario, Canada

    M Pintilie

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  1. T Seshadri
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  2. M Pintilie
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  4. M Crump
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Correspondence to T Seshadri.

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Seshadri, T., Pintilie, M., Keating, A. et al. The relationship between absolute lymphocyte count with PFS in patients with Hodgkin's lymphoma undergoing autologous hematopoietic cell transplant. Bone Marrow Transplant 42, 29–34 (2008). https://doi.org/10.1038/bmt.2008.41

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