Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Review
  • Published:

Stem cell transplantation programme at Singapore General Hospital

Abstract

The adult transplant programme at Singapore General Hospital (SGH) was established in 1985 and more than 820 transplants have been performed to date. An average of about 60 adult transplants (autologous and allogeneic) are performed each year. Transplants offered at SGH run the range from autologous to mismatched cord and unrelated transplants. Special interests of the transplant programme include non-myeloablative transplants in aplastic anaemia, cell therapy protocols including cytokine-induced killer cells, patterns of GVHD, cord blood transplantation for autoimmune diseases and graft engineering. A cGMP (good manufacturing practice) cell therapy laboratory was recently established to facilitate bench-to-bedside translational cell therapy trials. A BMT consortium has been formed among the various paediatric and adult transplant centres for harmonization of protocols and research activities.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1

Similar content being viewed by others

References

  1. Tan DCL, Hsu LY, Koh LP, Goh YT, Koh M . Severe conidiobolomycosis complicating induction chemotherapy in a patient with acute lymphoblastic leukaemia. Br J Haematol 2005; 129: 447.

    Article  Google Scholar 

  2. Cornely OA, Maertens J, Winston DJ, Perfect J, Ullmann AJ, Walsh TJ et al. Posaconazole vs fluconazole or itraconazole prophylaxis in patients with neutropenia. N Eng J Med 2007; 356: 348–359.

    Article  CAS  Google Scholar 

  3. Koh LP, Koh MBC, Goh YT, Tan P . Allogeneic HSCT for patients with severe aplastic anaemia following non myeloablative conditioning with 200 cGy TBI and fludarabine. Biol Bone Marrow Transplant 2006; 12: 887–890.

    Article  CAS  Google Scholar 

  4. Koh LP, Chen CS, Tai BC, Hwang WY, Tan LK, Koh MBC et al. The impact of post grafting immunosuppression on non relapse mortality and survival after non myeloablative transplantation using fludarabine and 200 cGy total body irradiation. Biol Blood Marrow Transplant 2007; 13: 790–805.

    Article  CAS  Google Scholar 

  5. Koh MBC, Prentice HG, Corbo M, Cotter FE, Morgan M, Lowdell MW . Alloantigen-specific T-cell depletion in a major histocompatibility complex fully mismatched murine model provides effective graft-versus-host disease prophylaxis in the presence of lymphoid engraftment. Br J Haematol 2002; 118: 108–116.

    Article  CAS  Google Scholar 

  6. Koh MBC, Lim TJ, Niam M, Suck G, Chan M, Goh YT et al. A Translational Clinical Trial to evaluate the safety and efficacy of graded infusions of ex-vivo expanded cytokine induced killer (CIK) cells for haematologic malignancies. Cytotherapy 2007, abstract.

  7. Linn YC, Wang SM, Hui KM . Comparative gene expression profiling of cytokine-induced killer cells in response to acute myloid leukemic and acute lymphoblastic leukemic stimulators using oligonucleotide arrays. Exp Haem 2005; 33: 671–681.

    Article  CAS  Google Scholar 

  8. Suck G . Novel approaches using natural killer cells in cancer therapy. Semin Cancer Biol 2006; 16: 412–418.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to M B C Koh.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Koh, M., Goh, Y., Tan, P. et al. Stem cell transplantation programme at Singapore General Hospital. Bone Marrow Transplant 42 (Suppl 1), S121–S124 (2008). https://doi.org/10.1038/bmt.2008.139

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/bmt.2008.139

Keywords

This article is cited by

Search

Quick links