Abstract
Immunohistochemical staining of bcl-2 and p53 proteins was compared with thymidine labelling index (TLI) and cell loss factor (O) in lung cancer. Neither bcl-2 nor p53 overexpression was associated with high cell loss but strong bcl-2 staining was associated with higher TLI. Concomitant strong p53 and bcl-2 expression, not the usual inverse relationship, plus high cell-loss factor was present in three neuroendocrine carcinomas. Other factors presumably have a role in controlling cell death in these tumours.
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Kennedy, M., Lamb, D., King, G. et al. Cell proliferation, cell loss and expression of bcl-2 and p53 in human pulmonary neoplasms. Br J Cancer 75, 545–547 (1997). https://doi.org/10.1038/bjc.1997.95
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DOI: https://doi.org/10.1038/bjc.1997.95
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