Abstract
To determine the relationship between breast cancer progression and gene amplification, we screened 62 distant metastases and 122 primary breast tumours for the amplification of the proto-oncogenes MYC and ERBB2 and the 11q13 chromosomal region. Surprisingly, solid metastases showed an absence of gene amplification. These results suggest that the amplification of the proto-oncogenes MYC and ERBB2 and the 11q13 chromosomal region seem to be involved mainly in the genesis of the primary breast tumour rather than its progression.
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Driouch, K., Champème, M., Beuzelin, M. et al. Classical gene amplifications in human breast cancer are not associated with distant solid metastases. Br J Cancer 76, 784–787 (1997). https://doi.org/10.1038/bjc.1997.462
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DOI: https://doi.org/10.1038/bjc.1997.462