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  • Clinical Oncology/Epidemiology
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Clinical Oncology/Epidemiology

Pharmacokinetics of doxorubicin co-administered with high-dose verapamil

British Journal of Cancer volume 71, pages 134–136 (1995)Cite this article

Abstract

The potential for the modification of the pharmacokinetics of doxorubicin (DOX) concurrently administered with high-dose verapamil (VER) has been investigated in 17 patients with advanced neoplasms refractory to drugs belonging to the multidrug resistance spectrum. Steady-state concentration of DOX, systemic clearance and urinary excretion were analysed. No significant difference was found between the kinetic parameters estimated for DOX at different levels of VER and those reported for doxorubicin as single agent. It can be concluded that VER does not appear to modify DOX kinetics.

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  1. Division of Experimental Oncology 1, Centro di Riferimento Oncologico, Aviano, Italy

    M Gigante

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  1. M Gigante
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  2. G Toffoli
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  3. M Boiocchi
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Gigante, M., Toffoli, G. & Boiocchi, M. Pharmacokinetics of doxorubicin co-administered with high-dose verapamil. Br J Cancer 71, 134–136 (1995). https://doi.org/10.1038/bjc.1995.27

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  • DOI: https://doi.org/10.1038/bjc.1995.27

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