Abstract
The human CCND1/PRAD1 gene, located in the 11q13 chromosomal region, encodes a cyclin D protein with potential oncogenic capacity and is involved in several human malignancies. The amplification and expression status of CCND1 was investigated in a series of oesophageal tumours. CCND1 is amplified in 54% and overexpressed in 63% of the tumours of the squamous cell type.
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Adélaide, J., Monges, G., Dérdérian, C. et al. Oesophageal cancer and amplification of the human cyclin D gene CCND1/PRAD1. Br J Cancer 71, 64–68 (1995). https://doi.org/10.1038/bjc.1995.13
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DOI: https://doi.org/10.1038/bjc.1995.13
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