Abstract
P-glycoprotein (Pgp) and pi-class glutathione S-transferase (GSTP1-1) are thought to be correlated with multiple drug resistance. In immunohistochemical staining, non-seminomatous germ cell tumours, which are more refractory than seminomas to anti-cancer chemotherapy, frequently expressed Pgp and GSTP1-1. Western blot analysis demonstrated lower amount of GSTP1-1 in seminoma than in teratoma. These results suggest that Pgp and GSTP1-1 might contribute to drug resistance in testis cancers.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 24 print issues and online access
$259.00 per year
only $10.79 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Katagiri, A., Tomita, Y., Nishiyama, T. et al. Immunohistochemical detection of P-glycoprotein and GSTP1-1 in testis cancer. Br J Cancer 68, 125–129 (1993). https://doi.org/10.1038/bjc.1993.299
Issue Date:
DOI: https://doi.org/10.1038/bjc.1993.299
This article is cited by
-
Behandlungsoptimierung fortgeschrittener testikulärer Keimzelltumoren
Der Urologe (2010)
-
Behandlungsoptimierung fortgeschrittener urologischer Malignome
Der Urologe (2007)
-
Suppression subtractive hybridization and expression profiling identifies a unique set of genes overexpressed in non-small-cell lung cancer
Oncogene (2004)
-
Lung resistance-related protein as a predictor of clinical outcome in advanced testicular germ-cell tumours
British Journal of Cancer (2003)
-
GlutathioneS-transferase expression in malignant mesothelioma and non-neoplastic mesothelium: an immunohistochemical study
Journal of Cancer Research and Clinical Oncology (1996)
