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  • Experimental Oncology
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Antigenic modulation of metastatic breast and ovary carcinoma cells by intracavitary injection of IFN-α

British Journal of Cancer volume 66, pages 342–344 (1992)Cite this article

Abstract

Antigenic modulation of major histocompatibility and tumour associated antigens was observed in neoplastic cells obtained from patients with pleural and abdominal effusions of breast and ovary carcinomas following a single intracavitary dose of 18 x 10(6) U recombinant IFN-alpha. This regimen resulted in antigenic modulation in seven out of 11 tested cases, suggesting a potential, although limited, responsiveness of at least a fraction of breast and ovary carcinoma cells to in situ biomodification with IFN-alpha.

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Authors and Affiliations

  1. Department of Pathology, Regina Elena Institute, Rome, Italy

    P Giacomini

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  1. P Giacomini
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  2. M Mottolese
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  3. R Fraioli
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  4. M Benevolo
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  5. I Venturo
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  6. PG Natali
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Giacomini, P., Mottolese, M., Fraioli, R. et al. Antigenic modulation of metastatic breast and ovary carcinoma cells by intracavitary injection of IFN-α. Br J Cancer 66, 342–344 (1992). https://doi.org/10.1038/bjc.1992.267

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  • DOI: https://doi.org/10.1038/bjc.1992.267

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