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  • Experimental Oncology
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Comparative effect of 6S, 6R and 6RS Leucovorin on methotrexate rescue and on modulation of 5-fluorouracil

British Journal of Cancer volume 63, pages 885–888 (1991)Cite this article

Abstract

The comparative efficacy of the pure diastereoisomers of leucovorin, the natural (6S) and the unnatural (6R) forms was compared to the racemic form (6RS). A protective effect in methotrexate-treated CCRF-CEM cells was obtained with 6S at concentrations 100-fold higher than those of methotrexate and with 6RS at concentrations 2-fold greater than those of 6S; however, at low concentrations of methotrexate, 6S was more effective than 6RS in preventing the cytotoxicity of methotrexate; on the opposite, 6R exhibited a protective effect at concentrations 10(4) higher than those of methotrexate. On the same cell line, 6S was shown to enhance the cytotoxic effect of 5 Fluorouracil exactly as 6RS while 6R did not exhibit any enhancing effect on cells exposed to 5 Fluorouracil.

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Authors and Affiliations

  1. Service Central d'Hématologie-Immunologie, Hôpital Henri Mondor Faculté de Médecine, Creteil, France

    J Zittoun

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  1. J Zittoun
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  2. J Marquet
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  3. JJ Pilorget
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  4. C Tonetti
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  5. E De Gialluly
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Zittoun, J., Marquet, J., Pilorget, J. et al. Comparative effect of 6S, 6R and 6RS Leucovorin on methotrexate rescue and on modulation of 5-fluorouracil. Br J Cancer 63, 885–888 (1991). https://doi.org/10.1038/bjc.1991.194

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  • DOI: https://doi.org/10.1038/bjc.1991.194

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