Abstract
A prospective, randomised controlled trial of surgery, surgery with adjuvant radiotherapy and surgery with adjuvant chemotherapy (5-fluorouracil, adriamycin and mitomycin C) in operable gastric cancer is described. Four hundred and thirty-six patients were randomly allocated to one of three treatment groups. With 12 months' minimum follow-up, 334 patients have died, 292 from recurrent cancer. The median survival for all patients was 15 months. Neither form of adjuvant therapy provides any survival advantage. Surgery remains the principal treatment for operable gastric cancer. Care should be taken to standardise surgical treatment and any adjuvant treatments must be compared within the confines of controlled, randomised trials.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 24 print issues and online access
$259.00 per year
only $10.79 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
Author information
Authors and Affiliations
Consortia
Rights and permissions
About this article
Cite this article
Allum, W., Hallissey, M., Ward, L. et al. A controlled, prospective, randomised trial of adjuvant chemotherapy or radiotherapy in resectable gastric cancer: interim report. Br J Cancer 60, 739–744 (1989). https://doi.org/10.1038/bjc.1989.350
Issue Date:
DOI: https://doi.org/10.1038/bjc.1989.350
This article is cited by
-
Post-surgery Survival in Patients with Adenocarcinoma of Stomach Using Multistate Model
Journal of Gastrointestinal Cancer (2022)
-
Radiotherapy for gastric cancer: a systematic review and meta-analysis
Tumor Biology (2014)
-
Preoperative chemoradiotherapy for locally advanced gastric cancer
Radiation Oncology (2013)
-
Intraoperative radiotherapy for the treatment of resectable locally advanced gastric adenocarcinoma: topography of locoregional recurrences and long-term outcomes
Clinical and Translational Oncology (2013)
-
Adjuvant postoperative radiochemotherapy for patients with gastric carcinoma: a single institution experience
The Chinese-German Journal of Clinical Oncology (2012)