Abstract
The therapeutic antitumour activity and host toxicity of cis-platin (CDDP), which was administered with selenium (sodium selenite) was studied on the growth of a human yolk sac tumour grown in nude mice. Treatment consisted of CDDP single agent chemotherapy (3 weeks) or preliminary PVB combination chemotherapy (CDDP + vinblastine + bleomycin, 2 weeks). Selenium was co-administered from day 1 to 5 with each therapeutic regimen. The administration of CDDP alone caused significant reduction in tumour burden but at higher doses there was significant host toxicity. The co-administration of selenium together with CDDP (CDDP: selenium, molar ratio = 3.5:1) did not affect the anti-tumour activity of CDDP but it did cause a decrease of parameters of host toxicity including lethality, increasing the 50% lethal dose (LD50) from 9.3 mg kg-1 to 17.5 mg kg-1. The parameters of host toxicity which were altered by selenium co-administration were nephrotoxicity, myeloid suppression and weight loss. Our study suggested that selenium co-administration allows higher doses of CDDP with reduction of apparent toxicity, resulting in a higher therapeutic index and possibly indicating a potential increase in the utilization of CDDP in clinical cancer chemotherapy.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 24 print issues and online access
$259.00 per year
only $10.79 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Ohkawa, K., Tsukada, Y., Dohzono, H. et al. The effects of co-administration of selenium and cis-platin (CDDP) on CDDP-induced toxicity and antitumour activity. Br J Cancer 58, 38–41 (1988). https://doi.org/10.1038/bjc.1988.157
Issue Date:
DOI: https://doi.org/10.1038/bjc.1988.157
This article is cited by
-
Theranostic applications of selenium nanomedicines against lung cancer
Journal of Nanobiotechnology (2023)
-
Die Rolle von antioxidativen Mikronährstoffen, Vitaminen und Selen in der Onkologie
Der Onkologe (2007)
-
The protective role of selenium on the toxicity of cisplatin-contained chemotherapy regimen in cancer patients
Biological Trace Element Research (1997)
-
An XRF study of trace elements accumulation in kidneys of tumor-bearing mice after treatment withcis-DDP with and without selenite and selenocistamine
Biological Trace Element Research (1994)
-
Factors affecting human autopsy kidney-cortex and kidney-medulla platinum concentrations after cisplatin administration
Cancer Chemotherapy and Pharmacology (1994)