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Thermal sensitivity of haemopoietic and stromal progenitor cells in different proliferative states

Abstract

Stromal progenitor cells (CFU-F) in normal mouse bone marrow were more sensitive to heat at 43 degrees C than haemopoietic progenitor cells (CFU-S and GM-CFC) by a factor of approximately 1.2. In marrow regenerating after 4.5 Gy X-rays, the changes in sensitivity were by less than a factor of 1.4 and the sensitivity of CFU-F changed slightly to become intermediate between that of CFU-S and GM-CFC. A comparison of sensitivities reported in the literature revealed an inexplicable large variation of up to a factor of 6 in the thermal sensitivities of CFU-S and GM-CFC.

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Wang, S., Hendry, J. & Testa, N. Thermal sensitivity of haemopoietic and stromal progenitor cells in different proliferative states. Br J Cancer 52, 51–54 (1985). https://doi.org/10.1038/bjc.1985.147

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  • DOI: https://doi.org/10.1038/bjc.1985.147

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